Molecular evidence for mitochondrial dysfunction in bipolar disorder - PubMed (original) (raw)
Molecular evidence for mitochondrial dysfunction in bipolar disorder
Christine Konradi et al. Arch Gen Psychiatry. 2004 Mar.
Erratum in
- Arch Gen Psychiatry. 2004 Jun;61(6):538
Abstract
Background: The disease mechanism of bipolar disorder remains unknown. Recent studies have provided evidence for abnormal gene expression in bipolar disorder.
Objective: To determine the expression of 12558 nuclear genes in the human hippocampus in healthy control subjects and those with bipolar disorder or schizophrenia.
Design: We used gene arrays to study messenger RNA expression. Data were verified with a real-time quantitative polymerase chain reaction assay.
Subjects: We studied 10 healthy control subjects, 9 subjects with bipolar disorder, and 8 subjects with schizophrenia.
Results: The expression of nuclear messenger RNA coding for mitochondrial proteins was significantly decreased in the hippocampus in subjects with bipolar disorder but not in those with schizophrenia. Subjects with bipolar disorder were characterized by a pronounced and extensive decrease in the expression of genes regulating oxidative phosphorylation and the adenosine triphosphate-dependent process of proteasome degradation.
Conclusions: These findings point toward a widespread dysregulation of mitochondrial energy metabolism and downstream deficits of adenosine triphosphate-dependent processes in bipolar disorder.
Similar articles
- Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia.
Munakata K, Iwamoto K, Bundo M, Kato T. Munakata K, et al. Biol Psychiatry. 2005 Mar 1;57(5):525-32. doi: 10.1016/j.biopsych.2004.11.041. Biol Psychiatry. 2005. PMID: 15737668 - Mitochondrial complex I subunits expression is altered in schizophrenia: a postmortem study.
Karry R, Klein E, Ben Shachar D. Karry R, et al. Biol Psychiatry. 2004 Apr 1;55(7):676-84. doi: 10.1016/j.biopsych.2003.12.012. Biol Psychiatry. 2004. PMID: 15038995 - Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder.
Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Tohyama M, Yoshikawa T, Mori N. Anitha A, et al. Biol Psychiatry. 2008 Apr 1;63(7):678-85. doi: 10.1016/j.biopsych.2007.07.010. Epub 2007 Sep 20. Biol Psychiatry. 2008. PMID: 17884020 - Gene expression profiling in schizophrenia and related mental disorders.
Iwamoto K, Kato T. Iwamoto K, et al. Neuroscientist. 2006 Aug;12(4):349-61. doi: 10.1177/1073858406287536. Neuroscientist. 2006. PMID: 16840711 Review. - Schizophrenia and bipolar disorder: similarities in pathogenic mechanisms but differences in neurodevelopment.
Walker J, Curtis V, Murray RM. Walker J, et al. Int Clin Psychopharmacol. 2002 Aug;17 Suppl 3:S11-9. Int Clin Psychopharmacol. 2002. PMID: 12570067 Review.
Cited by
- The metabolic overdrive hypothesis: hyperglycolysis and glutaminolysis in bipolar mania.
Campbell IH, Campbell H. Campbell IH, et al. Mol Psychiatry. 2024 May;29(5):1521-1527. doi: 10.1038/s41380-024-02431-w. Epub 2024 Jan 25. Mol Psychiatry. 2024. PMID: 38273108 Free PMC article. - Emerging Novel Treatments for Severe Mood Disorders Involving Cellular Plasticity Cascades.
Machado-Vieira R, Zarate CA Jr, Manji HK. Machado-Vieira R, et al. Curr Psychos Ther Rep. 2006 Dec;4(4):181-190. doi: 10.1007/BF02629394. Curr Psychos Ther Rep. 2006. PMID: 25620894 Free PMC article. - Inflammation as a Mechanism of Bipolar Disorder Neuroprogression.
Barichello T, Giridharan VV, Bhatti G, Sayana P, Doifode T, Macedo D, Quevedo J. Barichello T, et al. Curr Top Behav Neurosci. 2021;48:215-237. doi: 10.1007/7854_2020_173. Curr Top Behav Neurosci. 2021. PMID: 33040314 - Neural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic targets.
Carlson PJ, Singh JB, Zarate CA Jr, Drevets WC, Manji HK. Carlson PJ, et al. NeuroRx. 2006 Jan;3(1):22-41. doi: 10.1016/j.nurx.2005.12.009. NeuroRx. 2006. PMID: 16490411 Free PMC article. Review. - Regulation of axonal trafficking of cytochrome c oxidase IV mRNA.
Aschrafi A, Natera-Naranjo O, Gioio AE, Kaplan BB. Aschrafi A, et al. Mol Cell Neurosci. 2010 Apr;43(4):422-30. doi: 10.1016/j.mcn.2010.01.009. Epub 2010 Feb 6. Mol Cell Neurosci. 2010. PMID: 20144716 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical