Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development - PubMed (original) (raw)

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Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development

Hajime Fujisawa. J Neurobiol. 2004 Apr.

Abstract

The semaphorin receptors neuropilin and plexin were initially identified as antigens for monoclonal antibodies MAb-A5 and MAb-B2, which bind to specific neuropiles and plexiform layers within the Xenopus tadpole nervous systems, several years before the discovery of the first semaphorin. This article provides an overview of how neuropilin and plexin were discovered. In addition, it describes the functions of neuropilin in the signaling of chemorepulsive activities of class 3 semaphorins and roles of neuropilin-mediated semaphorin activities in the directional guidance of the peripheral nervous system (PNS) and integration of the peripheral ganglia.

Copyright 2004 Wiley Periodicals, Inc. J Neurobiol 59: 24-33, 2004

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