Adrenarche - physiology, biochemistry and human disease - PubMed (original) (raw)
Review
Adrenarche - physiology, biochemistry and human disease
Richard J Auchus et al. Clin Endocrinol (Oxf). 2004 Mar.
Abstract
Adrenarche refers to the onset of dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) production from the adrenal zona reticularis that can be detected at around 6 years of age. The phenotypic result of adrenarche is pubarche or the development of axillary and pubic hair that occurs in both girls and boys at about age 8. The phenomenon of adrenarche is unique to human beings and to some Old World primates, and a reversal of adrenarche appears to occur in the ageing process. Premature and exaggerated adrenarche can be indicative of future onset of adult diseases, thus increasing the clinical relevance of adrenarche. The physiological triggers of adrenarche and the role(s) of DHEA-S remain speculative. However, the biochemical pathways that define adrenarche have been characterized in detail, and the appearance of key enzymes and cofactors in the adrenal zona reticularis track with the progression of adrenarche. This article reviews the clinical manifestations of adrenarche, the biochemistry of the enzymes involved in DHEA-S production, and the cell biology of the adrenal zona reticularis.
Similar articles
- The physiology and biochemistry of adrenarche.
Auchus RJ. Auchus RJ. Endocr Dev. 2011;20:20-27. doi: 10.1159/000321209. Epub 2010 Dec 16. Endocr Dev. 2011. PMID: 21164255 Review. - Update on adrenarche.
Witchel SF, Pinto B, Burghard AC, Oberfield SE. Witchel SF, et al. Curr Opin Pediatr. 2020 Aug;32(4):574-581. doi: 10.1097/MOP.0000000000000928. Curr Opin Pediatr. 2020. PMID: 32692055 Free PMC article. Review. - The rise in adrenal androgen biosynthesis: adrenarche.
Havelock JC, Auchus RJ, Rainey WE. Havelock JC, et al. Semin Reprod Med. 2004 Nov;22(4):337-47. doi: 10.1055/s-2004-861550. Semin Reprod Med. 2004. PMID: 15635501 Review. - Reference values for serum dehydroepiandrosterone-sulphate in healthy children and adolescents with emphasis on the age of adrenarche and pubarche.
Guran T, Firat I, Yildiz F, Kaplan Bulut I, Dogru M, Bereket A. Guran T, et al. Clin Endocrinol (Oxf). 2015 May;82(5):712-8. doi: 10.1111/cen.12612. Epub 2014 Oct 21. Clin Endocrinol (Oxf). 2015. PMID: 25208296 - In the zone: understanding zona reticularis function and its transformation by adrenarche.
Bird IM. Bird IM. J Endocrinol. 2012 Aug;214(2):109-11. doi: 10.1530/JOE-12-0246. Epub 2012 Jun 14. J Endocrinol. 2012. PMID: 22700191
Cited by
- Dietary Intake of Selenium in Relation to Pubertal Development in Mexican Children.
Liu Y, Peterson KE, Sánchez BN, Jones AD, Cantoral A, Mercado-García A, Solano-González M, Ettinger AS, Téllez-Rojo MM. Liu Y, et al. Nutrients. 2019 Jul 14;11(7):1595. doi: 10.3390/nu11071595. Nutrients. 2019. PMID: 31337124 Free PMC article. - Obesity and the pubertal transition in girls and boys.
Burt Solorzano CM, McCartney CR. Burt Solorzano CM, et al. Reproduction. 2010 Sep;140(3):399-410. doi: 10.1530/REP-10-0119. Reproduction. 2010. PMID: 20802107 Free PMC article. Review. - Cellular Senescence in Adrenocortical Biology and Its Disorders.
Gao X, Li F, Liu B, Wang Y, Wang Y, Zhou H. Gao X, et al. Cells. 2021 Dec 9;10(12):3474. doi: 10.3390/cells10123474. Cells. 2021. PMID: 34943980 Free PMC article. Review. - The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
Miller WL, Auchus RJ. Miller WL, et al. Endocr Rev. 2011 Feb;32(1):81-151. doi: 10.1210/er.2010-0013. Epub 2010 Nov 4. Endocr Rev. 2011. PMID: 21051590 Free PMC article. Review. - Physiologic Course of Female Reproductive Function: A Molecular Look into the Prologue of Life.
Rojas J, Chávez-Castillo M, Olivar LC, Calvo M, Mejías J, Rojas M, Morillo J, Bermúdez V. Rojas J, et al. J Pregnancy. 2015;2015:715735. doi: 10.1155/2015/715735. Epub 2015 Dec 1. J Pregnancy. 2015. PMID: 26697222 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical