Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shock - PubMed (original) (raw)

. 2003 Nov;24(11):1747-52.

doi: 10.1016/j.peptides.2003.07.027.

Oscar Cirioni, Roberto Ghiselli, Federico Mocchegiani, Claudio Viticchi, Fiorenza Orlando, Giuseppina D'Amato, Maria Simona Del Prete, Wojciech Kamysz, Jerzy łLukasiak, Vittorio Saba, Giorgio Scalise

Affiliations

• PMID: 15019206
• DOI: 10.1016/j.peptides.2003.07.027

Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shock

Andrea Giacometti et al. Peptides. 2003 Nov.

Abstract

The therapeutic efficacy of protegrin peptide IB-367 was investigated in three rat models of septic shock: (i) rats injected intraperitoneally with 1mg Escherichia coli 0111:B4 lipopolysaccharide, (ii) rats given an intraperitoneal injection of 2 X 10(10) CFU of E. coli ATCC 25922, and (iii) rats in which intra-abdominal sepsis was induced via cecal ligation and puncture. All animals were randomized to receive parenterally isotonic sodium chloride solution, 1mg/kg of IB-367, 60mg/kg piperacillin and 1mg/kg of IB-367 plus 60mg/kg piperacillin. The peptide demonstrated lower level of antimicrobial activity than piperacillin, nevertheless it exhibited the dual properties of antimicrobial and antiendotoxin agent. Finally IB-367 and piperacillin association showed to be the most effective therapeutic approach.

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