The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration - PubMed (original) (raw)
Review
The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration
Linda J Porrino et al. Neurosci Biobehav Rev. 2004 Jan.
Abstract
Although neuroimaging investigations in human cocaine abusers have provided important insights into the brain changes that accompany drug use, the interpretation of reports in human abusers can be very difficult. Studies in nonhuman primates provide a way to systematically evaluate the structural and functional adaptations engendered by cocaine self-administration without the confounds of human research. Functional activity, measured with metabolic mapping methods, and markers of the dopamine system, assessed autoradiographically, were evaluated over the course of chronic cocaine self-administration (5 days, 3.3 months, and 15-22 months). Within the striatum the topography of these responses shifts dramatically over time. Changes in functional activity and alterations in the dopamine system occupy larger and larger portions of dorsal and ventral striatum with increasing durations of cocaine exposure. The growing impact of cocaine suggests that the elements of the behavioral repertoire outside of the influence of cocaine become smaller and smaller with increasing durations of exposure to drug use resulting in cocaine's dominance over all aspects of the addict's life.
Similar articles
- Chronic cocaine self-administration is associated with altered functional activity in the temporal lobes of non human primates.
Beveridge TJ, Smith HR, Daunais JB, Nader MA, Porrino LJ. Beveridge TJ, et al. Eur J Neurosci. 2006 Jun;23(11):3109-18. doi: 10.1111/j.1460-9568.2006.04788.x. Eur J Neurosci. 2006. PMID: 16820001 - Functional effects of cocaine self-administration in primate brain regions regulating cardiovascular function.
Beveridge TJ, Smith HR, Nader MA, Porrino LJ. Beveridge TJ, et al. Neurosci Lett. 2004 Nov 11;370(2-3):201-5. doi: 10.1016/j.neulet.2004.08.021. Neurosci Lett. 2004. PMID: 15488323 - Aggression and defeat: persistent effects on cocaine self-administration and gene expression in peptidergic and aminergic mesocorticolimbic circuits.
Miczek KA, Covington HE 3rd, Nikulina EM Jr, Hammer RP. Miczek KA, et al. Neurosci Biobehav Rev. 2004 Jan;27(8):787-802. doi: 10.1016/j.neubiorev.2003.11.005. Neurosci Biobehav Rev. 2004. PMID: 15019428 Review. - Changes in extracellular dopamine during cocaine self-administration in squirrel monkeys.
Kimmel HL, Ginsburg BC, Howell LL. Kimmel HL, et al. Synapse. 2005 Jun 1;56(3):129-34. doi: 10.1002/syn.20135. Synapse. 2005. PMID: 15765537 - Behavioral pharmacology of cocaine.
Fischman MW. Fischman MW. J Clin Psychiatry. 1988 Feb;49 Suppl:7-10. J Clin Psychiatry. 1988. PMID: 3276672 Review.
Cited by
- Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder.
Kohler RJ, Zhornitsky S, Potenza MN, Yip SW, Worhunsky P, Angarita GA. Kohler RJ, et al. Am J Drug Alcohol Abuse. 2024 May 3;50(3):345-356. doi: 10.1080/00952990.2024.2318585. Epub 2024 Mar 29. Am J Drug Alcohol Abuse. 2024. PMID: 38551365 Free PMC article. - Cue-induced reinstatement of seeking behavior in male rats is independent from the rewarding value of the primary reinforcer: Effect of mGluR5 blockade.
Kallupi M, Ciccocioppo R. Kallupi M, et al. Neuropharmacology. 2023 Dec 1;240:109694. doi: 10.1016/j.neuropharm.2023.109694. Epub 2023 Sep 1. Neuropharmacology. 2023. PMID: 37659439 Free PMC article. - The Effects of Drugs on Behavior Maintained by Social Contact: Role of Monoamines in Social Reinforcement.
Sharp JL, Smith MA. Sharp JL, et al. Front Behav Neurosci. 2022 Feb 21;15:805139. doi: 10.3389/fnbeh.2021.805139. eCollection 2021. Front Behav Neurosci. 2022. PMID: 35264935 Free PMC article. - Interaction between cocaine use and sleep behavior: A comprehensive review of cocaine's disrupting influence on sleep behavior and sleep disruptions influence on reward seeking.
Bjorness TE, Greene RW. Bjorness TE, et al. Pharmacol Biochem Behav. 2021 Jul;206:173194. doi: 10.1016/j.pbb.2021.173194. Epub 2021 May 1. Pharmacol Biochem Behav. 2021. PMID: 33940055 Free PMC article. Review. - Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in Rats.
Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Groman SM, et al. Biol Psychiatry. 2020 Nov 15;88(10):777-787. doi: 10.1016/j.biopsych.2020.06.020. Epub 2020 Jun 29. Biol Psychiatry. 2020. PMID: 32826065 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources