Absorption and metabolism of flavonoids - PubMed (original) (raw)
Review
Absorption and metabolism of flavonoids
Thomas Walle. Free Radic Biol Med. 2004.
Abstract
The benefits of flavonoids as chemopreventive dietary or dietary supplemental agents are still only "potential." Much has been learned about possible mechanisms of action of these agents, but whether they can reach their multiple intended sites of action, particularly in humans, is largely unknown. The biological fate of the flavonoids, including their dietary glycoside forms, is highly complex, dependent on a large number of processes. This review is intended to bring some order into this complex area and deals with the fate of the naturally occurring glycosides, their enzymatic hydrolysis, as well as the resulting aglycones. The impact of membrane transporters as well as metabolic enzymes on the cellular availability of these phytochemicals is examined. A reevaluation of the concept of oral bioavailability applied to the dietary flavonoids is presented.
Similar articles
- Methylated flavonoids have greatly improved intestinal absorption and metabolic stability.
Wen X, Walle T. Wen X, et al. Drug Metab Dispos. 2006 Oct;34(10):1786-92. doi: 10.1124/dmd.106.011122. Epub 2006 Jul 25. Drug Metab Dispos. 2006. PMID: 16868069 - Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.
Németh K, Plumb GW, Berrin JG, Juge N, Jacob R, Naim HY, Williamson G, Swallow DM, Kroon PA. Németh K, et al. Eur J Nutr. 2003 Jan;42(1):29-42. doi: 10.1007/s00394-003-0397-3. Eur J Nutr. 2003. PMID: 12594539 - Flavonoids and their glycosides, including anthocyanins.
Veitch NC, Grayer RJ. Veitch NC, et al. Nat Prod Rep. 2008 Jun;25(3):555-611. doi: 10.1039/b718040n. Epub 2008 Apr 10. Nat Prod Rep. 2008. PMID: 18497898 Review. - In vitro biological properties of flavonoid conjugates found in vivo.
Williamson G, Barron D, Shimoi K, Terao J. Williamson G, et al. Free Radic Res. 2005 May;39(5):457-69. doi: 10.1080/10715760500053610. Free Radic Res. 2005. PMID: 16036321 Review. - [Bioavailability and metabolism of flavonoids].
Makarova NM. Makarova NM. Eksp Klin Farmakol. 2011;74(6):33-40. Eksp Klin Farmakol. 2011. PMID: 21870774 Review. Russian.
Cited by
- Flavonoids: A treasure house of prospective pharmacological potentials.
Hasnat H, Shompa SA, Islam MM, Alam S, Richi FT, Emon NU, Ashrafi S, Ahmed NU, Chowdhury MNR, Fatema N, Hossain MS, Ghosh A, Ahmed F. Hasnat H, et al. Heliyon. 2024 Mar 9;10(6):e27533. doi: 10.1016/j.heliyon.2024.e27533. eCollection 2024 Mar 30. Heliyon. 2024. PMID: 38496846 Free PMC article. Review. - Hangeshashinto-Associated Mesenteric Phlebosclerosis and Highly Atypical Adenoma Requiring Laparoscopic Right Hemicolectomy.
Nishiwaki R, Inoue Y, Sugao M, Sugimasa N, Hamaguchi T, Noji M, Takeuchi K, Ito Y, Kato T, Yasuma T, D'Alessandoro-Gabazza CN, Gabazza EC, Imoto I. Nishiwaki R, et al. Diagnostics (Basel). 2024 Mar 6;14(5):565. doi: 10.3390/diagnostics14050565. Diagnostics (Basel). 2024. PMID: 38473037 Free PMC article. - An Update of Kaempferol Protection against Brain Damage Induced by Ischemia-Reperfusion and by 3-Nitropropionic Acid.
López-Sánchez C, Lagoa R, Poejo J, García-López V, García-Martínez V, Gutierrez-Merino C. López-Sánchez C, et al. Molecules. 2024 Feb 8;29(4):776. doi: 10.3390/molecules29040776. Molecules. 2024. PMID: 38398528 Free PMC article. Review. - Polymethoxylated flavonoids in citrus fruits: absorption, metabolism, and anticancer mechanisms against breast cancer.
Wang Y, Mou Y, Lu S, Xia Y, Cheng B. Wang Y, et al. PeerJ. 2024 Jan 3;12:e16711. doi: 10.7717/peerj.16711. eCollection 2024. PeerJ. 2024. PMID: 38188169 Free PMC article. - Phenylpropanoid-enriched broccoli seedling extract can reduce inflammatory markers and pain behavior.
Gurgul AA, Najjar Y, Chee A, An H, Che CT, Park TJ, Warpeha KM. Gurgul AA, et al. J Transl Med. 2023 Dec 19;21(1):922. doi: 10.1186/s12967-023-04777-1. J Transl Med. 2023. PMID: 38115032 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources