The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer - PubMed (original) (raw)

Review

. 2004 Mar 15;23(11):2028-36.

doi: 10.1038/sj.onc.1207389.

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• PMID: 15021890
• DOI: 10.1038/sj.onc.1207389

Review

The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

Serge Y Fuchs et al. Oncogene. 2004.

Abstract

Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits for the SCFbeta-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCFbeta-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying beta-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting beta-TrCP as a means of anticancer therapy are also discussed.

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