Effects of birthplace and individual genetic admixture on lung volume and exercise phenotypes of Peruvian Quechua - PubMed (original) (raw)
Clinical Trial
doi: 10.1002/ajpa.10319.
Affiliations
- PMID: 15022366
- DOI: 10.1002/ajpa.10319
Clinical Trial
Effects of birthplace and individual genetic admixture on lung volume and exercise phenotypes of Peruvian Quechua
Tom D Brutsaert et al. Am J Phys Anthropol. 2004 Apr.
Abstract
Forced vital capacity (FVC) and maximal exercise response were measured in two populations of Peruvian males (age, 18-35 years) at 4,338 m who differed by the environment in which they were born and raised, i.e., high altitude (Cerro de Pasco, Peru, BHA, n = 39) and sea level (Lima, Peru, BSL, n = 32). BSL subjects were transported from sea level to 4,338 m, and were evaluated within 24 hr of exposure to hypobaric hypoxia. Individual admixture level (ADMIX, % Spanish ancestry) was estimated for each subject, using 22 ancestry-informative genetic markers and also by skin reflectance measurement (MEL). Birthplace accounted for the approximately 10% larger FVC (P < 0.001), approximately 15% higher maximal oxygen consumption (VO(2)max, ml.min(-1).kg(-1)) (P < 0.001), and approximately 5% higher arterial oxygen saturation during exercise (SpO(2)) (P < 0.001) of BHA subjects. ADMIX was low in both study groups, averaging 9.5 +/- 2.6% and 2.1 +/- 0.3% in BSL and BHA subjects, respectively. Mean underarm MEL was significantly higher in the BSL group (P < 0.001), despite higher ADMIX. ADMIX was not associated with any study phenotype, but study power was not sufficient to evaluate hypotheses of genetic adaptation via the ADMIX variable. MEL and FVC were positively correlated in the BHA (P = 0.035) but not BSL (P = 0.335) subjects. However, MEL and ADMIX were not correlated across the entire study sample (P = 0.282). In summary, results from this study emphasize the importance of developmental adaptation to high altitude. While the MEL-FVC correlation may reflect genetic adaptation to high altitude, study results suggest that alternate (environmental) explanations be considered.
Copyright 2003 Wiley-Liss, Inc.
Similar articles
- Developmental and genetic components explain enhanced pulmonary volumes of female Peruvian Quechua.
Kiyamu M, Bigham A, Parra E, León-Velarde F, Rivera-Chira M, Brutsaert TD. Kiyamu M, et al. Am J Phys Anthropol. 2012 Aug;148(4):534-42. doi: 10.1002/ajpa.22069. Epub 2012 May 3. Am J Phys Anthropol. 2012. PMID: 22552823 - Higher arterial oxygen saturation during submaximal exercise in Bolivian Aymara compared to European sojourners and Europeans born and raised at high altitude.
Brutsaert TD, Araoz M, Soria R, Spielvogel H, Haas JD. Brutsaert TD, et al. Am J Phys Anthropol. 2000 Oct;113(2):169-81. doi: 10.1002/1096-8644(200010)113:2<169::AID-AJPA3>3.0.CO;2-9. Am J Phys Anthropol. 2000. PMID: 11002203 - Aerobic capacity of Peruvian Quechua: a test of the developmental adaptation hypothesis.
Kiyamu M, Rivera-Chira M, Brutsaert TD. Kiyamu M, et al. Am J Phys Anthropol. 2015 Mar;156(3):363-73. doi: 10.1002/ajpa.22655. Epub 2014 Nov 11. Am J Phys Anthropol. 2015. PMID: 25385548 - Population genetic aspects and phenotypic plasticity of ventilatory responses in high altitude natives.
Brutsaert TD. Brutsaert TD. Respir Physiol Neurobiol. 2007 Sep 30;158(2-3):151-60. doi: 10.1016/j.resp.2007.03.004. Epub 2007 Mar 12. Respir Physiol Neurobiol. 2007. PMID: 17400521 Review. - Perspectives on functional adaptation of the high altitude native.
Frisancho AR. Frisancho AR. Prog Clin Biol Res. 1983;136:383-407. Prog Clin Biol Res. 1983. PMID: 6364176 Review.
Cited by
- Trade-offs in relative limb length among Peruvian children: extending the thrifty phenotype hypothesis to limb proportions.
Pomeroy E, Stock JT, Stanojevic S, Miranda JJ, Cole TJ, Wells JC. Pomeroy E, et al. PLoS One. 2012;7(12):e51795. doi: 10.1371/journal.pone.0051795. Epub 2012 Dec 13. PLoS One. 2012. PMID: 23272169 Free PMC article. - Comparing high versus low-altitude populations to test human adaptations for increased ventilation during sustained aerobic activity.
Callison WÉ, Kiyamu M, Villafuerte FC, Brutsaert TD, Lieberman DE. Callison WÉ, et al. Sci Rep. 2022 Jul 1;12(1):11148. doi: 10.1038/s41598-022-13263-5. Sci Rep. 2022. PMID: 35778402 Free PMC article. - Two routes to functional adaptation: Tibetan and Andean high-altitude natives.
Beall CM. Beall CM. Proc Natl Acad Sci U S A. 2007 May 15;104 Suppl 1(Suppl 1):8655-60. doi: 10.1073/pnas.0701985104. Epub 2007 May 9. Proc Natl Acad Sci U S A. 2007. PMID: 17494744 Free PMC article. - Angiotensin-converting enzyme genotype and arterial oxygen saturation at high altitude in Peruvian Quechua.
Bigham AW, Kiyamu M, León-Velarde F, Parra EJ, Rivera-Ch M, Shriver MD, Brutsaert TD. Bigham AW, et al. High Alt Med Biol. 2008 Summer;9(2):167-78. doi: 10.1089/ham.2007.1066. High Alt Med Biol. 2008. PMID: 18578648 Free PMC article. - Phenotypic differences between highlanders and lowlanders in Papua New Guinea.
André M, Brucato N, Plutniak S, Kariwiga J, Muke J, Morez A, Leavesley M, Mondal M, Ricaut FX. André M, et al. PLoS One. 2021 Jul 21;16(7):e0253921. doi: 10.1371/journal.pone.0253921. eCollection 2021. PLoS One. 2021. PMID: 34288918 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous