Integrins and T cell-mediated immunity - PubMed (original) (raw)
Review
Integrins and T cell-mediated immunity
Jonathan T Pribila et al. Annu Rev Immunol. 2004.
Abstract
Integrin receptors mediate adhesive events that are critical for a specific and effective immune response to foreign pathogens. Integrin-dependent interactions of lymphocytes and antigen-presenting cells (APCs) to endothelium regulate the efficiency and specificity of trafficking into secondary lymphoid organs and peripheral tissue. Within these sites, integrins facilitate cell movement via interactions with the extracellular matrix, and promote and stabilize antigen-specific interactions between T lymphocytes and APCs that are critical for initiating T cell-activation events. In this review, we discuss the role of integrins in T cell-mediated immunity, with a focus on how these receptors participate in lymphocyte recirculation and T cell activation, how antigen stimulation regulates integrin activity, and how integrins define functionally unique subsets of T cells and APCs.
Similar articles
- Integrins in immunity.
Evans R, Patzak I, Svensson L, De Filippo K, Jones K, McDowall A, Hogg N. Evans R, et al. J Cell Sci. 2009 Jan 15;122(Pt 2):215-25. doi: 10.1242/jcs.019117. J Cell Sci. 2009. PMID: 19118214 Review. - Antigen-independent processes in antigen-specific immunity. A role for alpha 4 integrin.
Ferguson TA, Kupper TS. Ferguson TA, et al. J Immunol. 1993 Feb 15;150(4):1172-82. J Immunol. 1993. PMID: 8432974 - Signal transduction events regulating integrin function and T cell migration: new functions and complexity.
Pribila JT, Shimizu Y. Pribila JT, et al. Immunol Res. 2003;27(1):107-28. doi: 10.1385/ir:27:1:107. Immunol Res. 2003. PMID: 12637771 Review. - Antigen-independent, integrin-mediated T cell activation.
Sturmhöfel K, Brando C, Martinon F, Shevach EM, Coligan JE. Sturmhöfel K, et al. J Immunol. 1995 Mar 1;154(5):2104-11. J Immunol. 1995. PMID: 7532660
Cited by
- Transcriptome Analysis Reveals the Immunosuppression in Tiger Pufferfish (Takifugu rubripes) under Cryptocaryon irritans Infection.
Chi Y, Mukiibi R, Zhang H, Zhang H, Li W, Robledo D, Chen S, Li Y. Chi Y, et al. Animals (Basel). 2024 Jul 13;14(14):2058. doi: 10.3390/ani14142058. Animals (Basel). 2024. PMID: 39061520 Free PMC article. - Immune Cell Migration to Cancer.
Ryan AT, Kim M, Lim K. Ryan AT, et al. Cells. 2024 May 16;13(10):844. doi: 10.3390/cells13100844. Cells. 2024. PMID: 38786066 Free PMC article. Review. - T cell Ca2+ microdomains through the lens of computational modeling.
Gil Montoya DC, Ornelas-Guevara R, Diercks BP, Guse AH, Dupont G. Gil Montoya DC, et al. Front Immunol. 2023 Oct 4;14:1235737. doi: 10.3389/fimmu.2023.1235737. eCollection 2023. Front Immunol. 2023. PMID: 37860008 Free PMC article. Review. - An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity.
Szeto ACH, Ferreira ACF, Mannion J, Clark PA, Sivasubramaniam M, Heycock MWD, Crisp A, Jolin HE, Kozik P, Knolle MD, McKenzie ANJ. Szeto ACH, et al. Nat Immunol. 2023 Jan;24(1):123-135. doi: 10.1038/s41590-022-01378-w. Epub 2022 Dec 22. Nat Immunol. 2023. PMID: 36550322 Free PMC article. - From thymus to tissues and tumors: A review of T-cell biology.
Chopp L, Redmond C, O'Shea JJ, Schwartz DM. Chopp L, et al. J Allergy Clin Immunol. 2023 Jan;151(1):81-97. doi: 10.1016/j.jaci.2022.10.011. Epub 2022 Oct 19. J Allergy Clin Immunol. 2023. PMID: 36272581 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous