Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system - PubMed (original) (raw)
Comparative Study
doi: 10.1038/nn1214. Epub 2004 Mar 14.
Affiliations
- PMID: 15034587
- DOI: 10.1038/nn1214
Comparative Study
Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
Wei Fan et al. Nat Neurosci. 2004 Apr.
Abstract
Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.
Similar articles
- Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.
Halatchev IG, Ellacott KL, Fan W, Cone RD. Halatchev IG, et al. Endocrinology. 2004 Jun;145(6):2585-90. doi: 10.1210/en.2003-1754. Epub 2004 Mar 11. Endocrinology. 2004. PMID: 15016721 - The neuronal histamine H(1) and pro-opiomelanocortin-melanocortin 4 receptors: independent regulation of food intake and energy expenditure.
Yoshimatsu H. Yoshimatsu H. Peptides. 2006 Feb;27(2):326-32. doi: 10.1016/j.peptides.2005.02.028. Epub 2005 Dec 15. Peptides. 2006. PMID: 16343692 Review. - Neuronal activation in the hypothalamus and brainstem during feeding in rats.
Johnstone LE, Fong TM, Leng G. Johnstone LE, et al. Cell Metab. 2006 Oct;4(4):313-21. doi: 10.1016/j.cmet.2006.08.003. Cell Metab. 2006. PMID: 17011504 - Hypophagia induced by glucocorticoid deficiency is associated with an increased activation of satiety-related responses.
Uchoa ET, Sabino HA, Ruginsk SG, Antunes-Rodrigues J, Elias LL. Uchoa ET, et al. J Appl Physiol (1985). 2009 Feb;106(2):596-604. doi: 10.1152/japplphysiol.90865.2008. Epub 2008 Nov 20. J Appl Physiol (1985). 2009. PMID: 19023022 - The central melanocortin system and the integration of short- and long-term regulators of energy homeostasis.
Ellacott KL, Cone RD. Ellacott KL, et al. Recent Prog Horm Res. 2004;59:395-408. doi: 10.1210/rp.59.1.395. Recent Prog Horm Res. 2004. PMID: 14749511 Review.
Cited by
- Neural circuits regulation of satiation.
Cai H, Schnapp WI, Mann S, Miscevic M, Shcmit MB, Conteras M, Fang C. Cai H, et al. Appetite. 2024 Sep 1;200:107512. doi: 10.1016/j.appet.2024.107512. Epub 2024 May 25. Appetite. 2024. PMID: 38801994 Free PMC article. Review. - Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis.
Pan Y, Bu T, Deng X, Jia J, Yuan G. Pan Y, et al. Endocrine. 2024 Apr;84(1):1-15. doi: 10.1007/s12020-023-03640-z. Epub 2024 Jan 16. Endocrine. 2024. PMID: 38227168 Review. - CCK-sensitive C fibers activate NTS leptin receptor-expressing neurons via NMDA receptors.
Neyens DM, Brenner L, Calkins R, Winzenried ET, Ritter RC, Appleyard SM. Neyens DM, et al. Am J Physiol Regul Integr Comp Physiol. 2024 May 1;326(5):R383-R400. doi: 10.1152/ajpregu.00238.2022. Epub 2023 Dec 18. Am J Physiol Regul Integr Comp Physiol. 2024. PMID: 38105761 Free PMC article. - High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling.
Gruber T, Lechner F, Murat C, Contreras RE, Sanchez-Quant E, Miok V, Makris K, Le Thuc O, González-García I, García-Clave E, Althammer F, Krabichler Q, DeCamp LM, Jones RG, Lutter D, Williams RH, Pfluger PT, Müller TD, Woods SC, Pospisilik JA, Martinez-Jimenez CP, Tschöp MH, Grinevich V, García-Cáceres C. Gruber T, et al. Cell Rep. 2023 Oct 31;42(10):113305. doi: 10.1016/j.celrep.2023.113305. Cell Rep. 2023. PMID: 37864798 Free PMC article. - The biological functions and metabolic pathways of valine in swine.
Wang C, Peng Y, Zhang Y, Xu J, Jiang S, Wang L, Yin Y. Wang C, et al. J Anim Sci Biotechnol. 2023 Oct 7;14(1):135. doi: 10.1186/s40104-023-00927-z. J Anim Sci Biotechnol. 2023. PMID: 37805513 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous