Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics - PubMed (original) (raw)
Review
doi: 10.1038/nrm1310.
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- PMID: 15040442
- DOI: 10.1038/nrm1310
Review
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics
Lynne E Maquat. Nat Rev Mol Cell Biol. 2004 Feb.
Abstract
Studies of nonsense-mediated mRNA decay in mammalian cells have proffered unforeseen insights into changes in mRNA-protein interactions throughout the lifetime of an mRNA. Remarkably, mRNA acquires a complex of proteins at each exon-exon junction during pre-mRNA splicing that influences the subsequent steps of mRNA translation and nonsense-mediated mRNA decay. Complex-loaded mRNA is thought to undergo a pioneer round of translation when still bound by cap-binding proteins CBP80 and CBP20 and poly(A)-binding protein 2. The acquisition and loss of mRNA-associated proteins accompanies the transition from the pioneer round to subsequent rounds of translation, and from translational competence to substrate for nonsense-mediated mRNA decay.
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