Screening decreases prostate cancer mortality: 11-year follow-up of the 1988 Quebec prospective randomized controlled trial - PubMed (original) (raw)
Clinical Trial
. 2004 May 15;59(3):311-8.
doi: 10.1002/pros.20017.
Affiliations
- PMID: 15042607
- DOI: 10.1002/pros.20017
Clinical Trial
Screening decreases prostate cancer mortality: 11-year follow-up of the 1988 Quebec prospective randomized controlled trial
Fernand Labrie et al. Prostate. 2004.
Abstract
Purpose: This clinical trial is aimed at evaluating the impact of prostate cancer screening on cancer-specific mortality.
Subjects and methods: Forty-six thousand four hundred and eighty-six (46,486) men aged 45-80 years registered in the electoral roll of the Quebec city area were randomized in 1988 between screening and no screening. Screening included measurement of serum prostatic specific antigen (PSA) using 3.0 ng/ml as upper limit of normal and digital rectal examination (DRE) at first visit. At follow-up visits, serum PSA only was used.
Results: Seventy-four (74) deaths from prostate cancer occurred in the 14,231 unscreened controls while 10 deaths were observed in the screened group of 7,348 men during the first 11 years following randomization. Median follow-up of screened men was 7.93 years. A Cox proportional hazards model of the age at death from prostate cancer shows a 62% reduction (P < 0.002, Fisher's exact test) of cause-specific mortality in the screened men (P = 0.005). These results are in agreement with the continuous decrease of prostate cancer mortality observed in North America.
Copyright 2004 Wiley-Liss, Inc.
Comment in
- A misleading paper on prostate cancer screening.
Elwood M. Elwood M. Prostate. 2004 Dec 1;61(4):372; author reply 373-4. doi: 10.1002/pros.20160. Prostate. 2004. PMID: 15503318 No abstract available. - Results of a randomized controlled trail of prostate cancer screening.
Pinsky PF. Pinsky PF. Prostate. 2004 Dec 1;61(4):371. doi: 10.1002/pros.20165. Prostate. 2004. PMID: 15503321 Clinical Trial. No abstract available.
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