WebQTL: web-based complex trait analysis - PubMed (original) (raw)

Comparative Study

doi: 10.1385/NI:1:4:299.

Affiliations

• PMID: 15043217
• DOI: 10.1385/NI:1:4:299

Comparative Study

WebQTL: web-based complex trait analysis

Jintao Wang et al. Neuroinformatics. 2003.

Abstract

WebQTL is a website that combines databases of complex traits with fast software for mapping quantitative trait loci (QTLs) and for searching for correlations among traits. WebQTL also includes well-curated genotype data for five sets of mouse recombinant inbred (RI) lines. Thus, to identify QTLs, users need provide only quantitative trait data from one of the supported populations. The WebQTL databases include both biological traits--neuroanatomical, pharmacological, and behavioral traits--and microarray-based gene expression data from BXD RI lines. A search function finds correlations between RNA expression and biological traits, and mapping functions find QTLs for either type of trait. The WebQTL service is available at http://www.webqtl.org/.

PubMed Disclaimer

Similar articles

• Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes.
  Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW. Chesler EJ, et al. Neuroinformatics. 2003;1(4):343-57. doi: 10.1385/NI:1:4:343. Neuroinformatics. 2003. PMID: 15043220
• Genetics of body weight in the LXS recombinant inbred mouse strains.
  Bennett B, Carosone-Link PJ, Lu L, Chesler EJ, Johnson TE. Bennett B, et al. Mamm Genome. 2005 Oct;16(10):764-74. doi: 10.1007/s00335-005-0002-6. Epub 2005 Oct 29. Mamm Genome. 2005. PMID: 16261418
• Informatics center for mouse genomics: the dissection of complex traits of the nervous system.
  Rosen GD, La Porte NT, Diechtiareff B, Pung CJ, Nissanov J, Gustafson C, Bertrand L, Gefen S, Fan Y, Tretiak OJ, Manly KF, Park MR, Williams AG, Connolly MT, Capra JA, Williams RW. Rosen GD, et al. Neuroinformatics. 2003;1(4):327-42. doi: 10.1385/NI:1:4:327. Neuroinformatics. 2003. PMID: 15043219
• Use of recombinant inbred strains to detect quantitative trait loci associated with behavior.
  Plomin R, McClearn GE, Gora-Maslak G, Neiderhiser JM. Plomin R, et al. Behav Genet. 1991 Mar;21(2):99-116. doi: 10.1007/BF01066330. Behav Genet. 1991. PMID: 2049054 Review.
• eQTL analysis in mice and rats.
  Tesson BM, Jansen RC. Tesson BM, et al. Methods Mol Biol. 2009;573:285-309. doi: 10.1007/978-1-60761-247-6_16. Methods Mol Biol. 2009. PMID: 19763934 Review.

Cited by

• New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork.
  Chunduri A, Watson PM, Ashbrook DG. Chunduri A, et al. Genes (Basel). 2022 Mar 29;13(4):614. doi: 10.3390/genes13040614. Genes (Basel). 2022. PMID: 35456420 Free PMC article.
• Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose.
  Senko AN, Overall RW, Silhavy J, Mlejnek P, Malínská H, Hüttl M, Marková I, Fabel KS, Lu L, Stuchlik A, Williams RW, Pravenec M, Kempermann G. Senko AN, et al. PLoS Genet. 2022 Apr 4;18(4):e1009638. doi: 10.1371/journal.pgen.1009638. eCollection 2022 Apr. PLoS Genet. 2022. PMID: 35377872 Free PMC article.
• Leveraging the cell lineage to predict cell-type specificity of regulatory variation from bulk genomics.
  Yankovitz G, Cohn O, Bacharach E, Peshes-Yaloz N, Steuerman Y, Iraqi FA, Gat-Viks I. Yankovitz G, et al. Genetics. 2021 Apr 15;217(4):iyab016. doi: 10.1093/genetics/iyab016. Genetics. 2021. PMID: 33734353 Free PMC article.
• Characterizing modifier genes of cardiac fibrosis phenotype in hypertrophic cardiomyopathy.
  Xu F, Chen Y, Tillman KA, Cui Y, Williams RW, Bhattacharya SK, Lu L, Sun Y. Xu F, et al. Int J Cardiol. 2021 May 1;330:135-141. doi: 10.1016/j.ijcard.2021.01.047. Epub 2021 Jan 30. Int J Cardiol. 2021. PMID: 33529666 Free PMC article.
• A platform for experimental precision medicine: The extended BXD mouse family.
  Ashbrook DG, Arends D, Prins P, Mulligan MK, Roy S, Williams EG, Lutz CM, Valenzuela A, Bohl CJ, Ingels JF, McCarty MS, Centeno AG, Hager R, Auwerx J, Lu L, Williams RW. Ashbrook DG, et al. Cell Syst. 2021 Mar 17;12(3):235-247.e9. doi: 10.1016/j.cels.2020.12.002. Epub 2021 Jan 19. Cell Syst. 2021. PMID: 33472028 Free PMC article.

References

1. 1. Lab Anim (NY). 2001 Jul-Aug;30(7):44-52 - PubMed
2. 1. Genome Res. 2002 Jun;12(6):996-1006 - PubMed
3. 1. Nat Rev Genet. 2002 Jan;3(1):11-21 - PubMed
4. 1. Genome Biol. 2001;2(11):RESEARCH0046 - PubMed
5. 1. Neuroinformatics. 2003;1(4):327-42 - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Springer

• Other Literature Sources

  • The Lens - Patent Citations

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)