Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission - PubMed (original) (raw)

. 2004 Mar 26;303(5666):2019-22.

doi: 10.1126/science.1093137.

Julie M Decker, Frederic Bibollet-Ruche, John L Mokili, Mark Muldoon, Scott A Denham, Marintha L Heil, Francis Kasolo, Rosemary Musonda, Beatrice H Hahn, George M Shaw, Bette T Korber, Susan Allen, Eric Hunter

Affiliations

• PMID: 15044802
• DOI: 10.1126/science.1093137

Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission

Cynthia A Derdeyn et al. Science. 2004.

Abstract

Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.

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Comment in

• Virology. HIV may shed some protection as it jumps to new hosts.
  Cohen J. Cohen J. Science. 2004 Mar 26;303(5666):1956. doi: 10.1126/science.303.5666.1956. Science. 2004. PMID: 15044774 No abstract available.

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