Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion - PubMed (original) (raw)
Case Reports
doi: 10.1002/ana.20016.
Affiliations
- PMID: 15048884
- DOI: 10.1002/ana.20016
Case Reports
Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion
Michael H Barnett et al. Ann Neurol. 2004 Apr.
Abstract
The study describes the clinical and pathological findings in 12 patients with relapsing and remitting multiple sclerosis, who died during or shortly after the onset of a relapse. Pathological changes not previously associated with the formation of new symptomatic lesions were observed in seven cases, namely, extensive oligodendrocyte apoptosis and microglial activation in myelinated tissue containing few or no lymphocytes or myelin phagocytes. No current laboratory model of multiple sclerosis, in particular, experimental allergic encephalomyelitis, is known with these features, which raises the possibility of some novel process underlying new lesion formation in multiple sclerosis.
Comment in
- Evidence for pathogenic heterogeneity in multiple sclerosis.
Lucchinetti CF, Bruck W, Lassmann H. Lucchinetti CF, et al. Ann Neurol. 2004 Aug;56(2):308. doi: 10.1002/ana.20182. Ann Neurol. 2004. PMID: 15293289 No abstract available. - Oligodendrocyte apoptosis before immune attack in multiple sclerosis?
Pender MP. Pender MP. Ann Neurol. 2005 Jan;57(1):158; author reply 158-9. doi: 10.1002/ana.20352. Ann Neurol. 2005. PMID: 15622546 No abstract available.
Similar articles
- Significance of T2 lesions in multiple sclerosis: A 13-year longitudinal study.
Rudick RA, Lee JC, Simon J, Fisher E. Rudick RA, et al. Ann Neurol. 2006 Aug;60(2):236-42. doi: 10.1002/ana.20883. Ann Neurol. 2006. PMID: 16786526 - Early diffuse demyelinating lesion in the cervical spinal cord predicts a worse prognosis in relapsing-remitting multiple sclerosis.
Coret F, Bosca I, Landete L, Magraner MJ, Navarré A, León JL, Casanova B. Coret F, et al. Mult Scler. 2010 Aug;16(8):935-41. doi: 10.1177/1352458510371960. Epub 2010 Jun 23. Mult Scler. 2010. PMID: 20573640 - Multiple sclerosis: novel perspectives on newly forming lesions.
Matute C, Pérez-Cerdá F. Matute C, et al. Trends Neurosci. 2005 Apr;28(4):173-5. doi: 10.1016/j.tins.2005.01.006. Trends Neurosci. 2005. PMID: 15808350 Review. - The pathology of primary progressive multiple sclerosis.
Brück W, Lucchinetti C, Lassmann H. Brück W, et al. Mult Scler. 2002 Apr;8(2):93-7. doi: 10.1191/1352458502ms785rr. Mult Scler. 2002. PMID: 11990878 Review.
Cited by
- Interferon-γ activates nuclear factor-κ B in oligodendrocytes through a process mediated by the unfolded protein response.
Lin Y, Jamison S, Lin W. Lin Y, et al. PLoS One. 2012;7(5):e36408. doi: 10.1371/journal.pone.0036408. Epub 2012 May 4. PLoS One. 2012. PMID: 22574154 Free PMC article. - Pathoetiology of multiple sclerosis: are we barking up the wrong tree?
Stys PK. Stys PK. F1000Prime Rep. 2013 Jun 3;5:20. doi: 10.12703/P5-20. Print 2013. F1000Prime Rep. 2013. PMID: 23755367 Free PMC article. - Investigation of sequential growth factor delivery during cuprizone challenge in mice aimed to enhance oligodendrogliogenesis and myelin repair.
Sabo JK, Aumann TD, Kilpatrick TJ, Cate HS. Sabo JK, et al. PLoS One. 2013 May 1;8(5):e63415. doi: 10.1371/journal.pone.0063415. Print 2013. PLoS One. 2013. PMID: 23650566 Free PMC article. - Polymorphisms in the genes coding for iron binding and transporting proteins are associated with disability, severity, and early progression in multiple sclerosis.
Gemmati D, Zeri G, Orioli E, De Gaetano FE, Salvi F, Bartolomei I, D'Alfonso S, Dall'osso C, Leone MA, Singh AV, Asselta R, Zamboni P. Gemmati D, et al. BMC Med Genet. 2012 Aug 10;13:70. doi: 10.1186/1471-2350-13-70. BMC Med Genet. 2012. PMID: 22883388 Free PMC article. - Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in experimental autoimmune encephalomyelitis through inhibiting GDNF signaling.
Jin L, Zhang J, Hua X, Xu X, Li J, Wang J, Wang M, Liu H, Qiu H, Chen M, Zhang X, Wang Y, Huang Z. Jin L, et al. Cell Death Dis. 2022 Sep 2;13(9):759. doi: 10.1038/s41419-022-05202-z. Cell Death Dis. 2022. PMID: 36055989 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources