CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans - PubMed (original) (raw)

Review

doi: 10.1007/s00251-004-0668-z. Epub 2004 Apr 1.

Sally Boxall, Andrea Bennett, Pontiano Kaleebu, Christine Watera, Jimmy Whitworth, Neil French, Ritu Dawes, Adrian V S Hill, Walter Bodmer, Peter C L Beverley, Elma Z Tchilian

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Review

CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans

Tara Stanton et al. Immunogenetics. 2004 May.

Abstract

The CD45 (leucocyte common) antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor signalling in lymphocytes, and expression of different CD45 isoforms is associated with distinct functions. Here we describe a novel polymorphism in exon 4 (A54G) of the gene encoding CD45 (PTPRC) that results in an amino acid substitution of Thr-19 to Ala in exon 4. The 54G allele was identified in African Ugandan populations and was found with a suggestive but not statistically significant increase in frequency amongst HIV-seropositive Ugandans. This suggests that the 54G variant and CD45 splicing abnormalities might be associated with HIV infection.

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