CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans - PubMed (original) (raw)
Review
doi: 10.1007/s00251-004-0668-z. Epub 2004 Apr 1.
Sally Boxall, Andrea Bennett, Pontiano Kaleebu, Christine Watera, Jimmy Whitworth, Neil French, Ritu Dawes, Adrian V S Hill, Walter Bodmer, Peter C L Beverley, Elma Z Tchilian
Affiliations
- PMID: 15057492
- DOI: 10.1007/s00251-004-0668-z
Review
CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans
Tara Stanton et al. Immunogenetics. 2004 May.
Abstract
The CD45 (leucocyte common) antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor signalling in lymphocytes, and expression of different CD45 isoforms is associated with distinct functions. Here we describe a novel polymorphism in exon 4 (A54G) of the gene encoding CD45 (PTPRC) that results in an amino acid substitution of Thr-19 to Ala in exon 4. The 54G allele was identified in African Ugandan populations and was found with a suggestive but not statistically significant increase in frequency amongst HIV-seropositive Ugandans. This suggests that the 54G variant and CD45 splicing abnormalities might be associated with HIV infection.
References
- Nat Genet. 2001 Sep;29(1):23-4 - PubMed
- Nat Med. 2000 Mar;6(3):343-5 - PubMed
- Annu Rev Immunol. 2003;21:107-37 - PubMed
- Immunogenetics. 2002 Jun;54(3):158-63 - PubMed
- Nat Med. 2002 Apr;8(4):379-85 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous