Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's sarcoma - PubMed (original) (raw)
Review
Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's sarcoma
B Ensoli et al. Immunol Rev. 1992 Jun.
Abstract
In the past, the study of KS pathogenesis has been hampered by the lack of in vitro and in vivo experimental systems. Recently, the establishment of long-term cultures of KS spindle cells and the development of animal models have allowed a variety of studies on the pathobiology of the disease. The results from these studies, reviewed herein, indicate that KS is a cytokine-mediated disease and that inflammatory and angiogenic cytokines and the HIV-1 Tat protein cooperate in its induction and progression in HIV-1-infected individuals.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous