Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells - PubMed (original) (raw)

. 2004 May 28;304(5675):1338-40.

doi: 10.1126/science.1095505. Epub 2004 Apr 1.

Affiliations

• PMID: 15060285
• DOI: 10.1126/science.1095505

Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells

Qin Shen et al. Science. 2004.

Abstract

Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood vessel component cells. We show that endothelial cells but not vascular smooth muscle cells release soluble factors that stimulate the self-renewal of neural stem cells, inhibit their differentiation, and enhance their neuron production. Both embryonic and adult neural stem cells respond, allowing extensive production of both projection neuron and interneuron types in vitro. Endothelial coculture stimulates neuroepithelial cell contact, activating Notch and Hes 1 to promote self-renewal. These findings identify endothelial cells as a critical component of the neural stem cell niche.

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Comment in

• Neuroscience. Cellular interactions in the stem cell niche.
  Wurmser AE, Palmer TD, Gage FH. Wurmser AE, et al. Science. 2004 May 28;304(5675):1253-5. doi: 10.1126/science.1099344. Science. 2004. PMID: 15166350 No abstract available.

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