Small-molecule inhibitors of protein-protein interactions: progressing towards the dream - PubMed (original) (raw)

Review

doi: 10.1038/nrd1343.

Affiliations

• PMID: 15060526
• DOI: 10.1038/nrd1343

Review

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

Michelle R Arkin et al. Nat Rev Drug Discov. 2004 Apr.

No abstract available

PubMed Disclaimer

Similar articles

• Protein-protein interactions as targets for small-molecule therapeutics in cancer.
  White AW, Westwell AD, Brahemi G. White AW, et al. Expert Rev Mol Med. 2008 Mar 19;10:e8. doi: 10.1017/S1462399408000641. Expert Rev Mol Med. 2008. PMID: 18353193 Review.
• Emerging classes of protein-protein interaction inhibitors and new tools for their development.
  Pagliaro L, Felding J, Audouze K, Nielsen SJ, Terry RB, Krog-Jensen C, Butcher S. Pagliaro L, et al. Curr Opin Chem Biol. 2004 Aug;8(4):442-9. doi: 10.1016/j.cbpa.2004.06.006. Curr Opin Chem Biol. 2004. PMID: 15288255 Review.
• Small molecule antagonists of proteins.
  Gadek TR, Nicholas JB. Gadek TR, et al. Biochem Pharmacol. 2003 Jan 1;65(1):1-8. doi: 10.1016/s0006-2952(02)01479-x. Biochem Pharmacol. 2003. PMID: 12473372 Review.
• Inhibition of protein-protein interactions using designed molecules.
  Wilson AJ. Wilson AJ. Chem Soc Rev. 2009 Dec;38(12):3289-300. doi: 10.1039/b807197g. Epub 2009 Jul 27. Chem Soc Rev. 2009. PMID: 20449049 Review.
• Between a rock and a hard place?
  Whitty A, Kumaravel G. Whitty A, et al. Nat Chem Biol. 2006 Mar;2(3):112-8. doi: 10.1038/nchembio0306-112. Nat Chem Biol. 2006. PMID: 16484997 Review.

Cited by

• Optimization of CD4/gp120 inhibitors by thermodynamic-guided alanine-scanning mutagenesis.
  Liu Y, Schön A, Freire E. Liu Y, et al. Chem Biol Drug Des. 2013 Jan;81(1):72-8. doi: 10.1111/cbdd.12075. Chem Biol Drug Des. 2013. PMID: 23066870 Free PMC article.
• Deregulations in the cyclin-dependent kinase-9-related pathway in cancer: implications for drug discovery and development.
  Romano G. Romano G. ISRN Oncol. 2013 Jun 6;2013:305371. doi: 10.1155/2013/305371. Print 2013. ISRN Oncol. 2013. PMID: 23840966 Free PMC article.
• Epitope-guided engineering of monobody binders for in vivo inhibition of Erk-2 signaling.
  Mann JK, Wood JF, Stephan AF, Tzanakakis ES, Ferkey DM, Park S. Mann JK, et al. ACS Chem Biol. 2013 Mar 15;8(3):608-16. doi: 10.1021/cb300579e. Epub 2012 Dec 18. ACS Chem Biol. 2013. PMID: 23227961 Free PMC article.
• Identification of the minimum pharmacophore of lipid-phosphatidylserine (PS) binding peptide-peptoid hybrid PPS1D1.
  Singh J, Shukla SP, Desai TJ, Udugamasooriya DG. Singh J, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4470-4477. doi: 10.1016/j.bmc.2016.07.045. Epub 2016 Jul 21. Bioorg Med Chem. 2016. PMID: 27485601 Free PMC article.
• Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3.
  Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang J. Song X, et al. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5. doi: 10.1073/pnas.1604274113. Epub 2016 Apr 15. Proc Natl Acad Sci U S A. 2016. PMID: 27084884 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database