Resolution of sister telomere association is required for progression through mitosis - PubMed (original) (raw)
. 2004 Apr 2;304(5667):97-100.
doi: 10.1126/science.1094754.
Affiliations
- PMID: 15064417
- DOI: 10.1126/science.1094754
Resolution of sister telomere association is required for progression through mitosis
Jasmin N Dynek et al. Science. 2004.
Abstract
Cohesins keep sister chromatids associated from the time of their replication in S phase until the onset of anaphase. In vertebrate cells, two distinct pathways dissociate cohesins, one acts on chromosome arms and the other on centromeres. Here, we describe a third pathway that acts on telomeres. Knockdown of tankyrase 1, a telomeric poly(ADP-ribose) polymerase caused mitotic arrest. Chromosomes aligned normally on the metaphase plate but were unable to segregate. Sister chromatids separated at centromeres and arms but remained associated at telomeres, apparently through proteinaceous bridges. Thus, telomeres may require a unique tankyrase 1-dependent mechanism for sister chromatid resolution before anaphase.
Comment in
- Cell biology. Telomere wedding ends in divorce.
Azzalin CM, Lingner J. Azzalin CM, et al. Science. 2004 Apr 2;304(5667):60-2. doi: 10.1126/science.1096809. Science. 2004. PMID: 15064409 No abstract available.
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