Rapid rewiring of arcuate nucleus feeding circuits by leptin - PubMed (original) (raw)

. 2004 Apr 2;304(5667):110-5.

doi: 10.1126/science.1089459.

Affiliations

• PMID: 15064421
• DOI: 10.1126/science.1089459

Rapid rewiring of arcuate nucleus feeding circuits by leptin

Shirly Pinto et al. Science. 2004.

Abstract

The fat-derived hormone leptin regulates energy balance in part by modulating the activity of neuropeptide Y and proopiomelanocortin neurons in the hypothalamic arcuate nucleus. To study the intrinsic activity of these neurons and their responses to leptin, we generated mice that express distinct green fluorescent proteins in these two neuronal types. Leptin-deficient (ob/ob) mice differed from wild-type mice in the numbers of excitatory and inhibitory synapses and postsynaptic currents onto neuropeptide Y and proopiomelanocortin neurons. When leptin was delivered systemically to ob/ob mice, the synaptic density rapidly normalized, an effect detectable within 6 hours, several hours before leptin's effect on food intake. These data suggest that leptin-mediated plasticity in the ob/ob hypothalamus may underlie some of the hormone's behavioral effects.

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Comment in

• Neuroscience. The fat-brain axis enters a new dimension.
  Elmquist JK, Flier JS. Elmquist JK, et al. Science. 2004 Apr 2;304(5667):63-4. doi: 10.1126/science.1096746. Science. 2004. PMID: 15064411 No abstract available.

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