Inhibition of GABA release by presynaptic ionotropic GABA receptors in hippocampal CA3 - PubMed (original) (raw)
Inhibition of GABA release by presynaptic ionotropic GABA receptors in hippocampal CA3
Nikolai Axmacher et al. Neuroreport. 2004.
Free article
Abstract
Vesicular transmitter release can be regulated by transmitter-gated ion channels at presynaptic axon terminals. The central inhibitory transmitter GABA acts on such presynaptic ionotropic receptors in various cells, including inhibitory interneurons. Here we report that GABA-mediated postsynaptic inhibitory currents in CA3 pyramidal cells of rat hippocampal slices are suppressed by agonists of GABAA receptors. The effect is present for both stimulus-induced and miniature IPSCs, indicating a reduction in the probability of vesicular release by presynaptic, action-potential-independent mechanisms. We conclude that the release of GABA from hippocampal CA3 interneurons is regulated by a negative feedback via presynaptic ionotropic GABA autoreceptors.
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