Probiotics in inflammatory bowel disease: is it all gut flora modulation? - PubMed (original) (raw)

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Probiotics in inflammatory bowel disease: is it all gut flora modulation?

S Ghosh et al. Gut. 2004 May.

No abstract available

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Figure 1

Pathogen associated molecular patterns (PAMPs) derived from bacteria (including probiotics) are recognised by pattern recognition receptors (PRRs, such as Toll-like receptors). Initiation of dendritic cell (DC) maturation starts after ligation of PRRs, which also requires adaptor proteins such as MyD88 for signalling. Type of PAMPs determines the selective priming of DCs for production of TH1, TH2, and TReg lymphocyte polarising factors. Different PAMPs ligate to specific corresponding PRRs. IL, interleukin; TNF, tumour necrosis factor; TGF-β, transforming growth factor β.

Comment on

• Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis.
  Sheil B, McCarthy J, O'Mahony L, Bennett MW, Ryan P, Fitzgibbon JJ, Kiely B, Collins JK, Shanahan F. Sheil B, et al. Gut. 2004 May;53(5):694-700. doi: 10.1136/gut.2003.027789. Gut. 2004. PMID: 15082588 Free PMC article.

References

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