An overview of serum antibody responses to influenza virus antigens - PubMed (original) (raw)
Affiliations
- PMID: 15088772
Review
An overview of serum antibody responses to influenza virus antigens
R B Couch. Dev Biol (Basel). 2003.
Abstract
Serum antibody responses after exposure to influenza virus antigens follow expected patterns for protein antigens. Induction of primary responses occurs in organized lymphoid tissues while secondary responses may occur in the periphery; in primary responses, IgM antibody is initially dominant whereas IgG antibody is dominant in secondary responses. Serum antibody responses have been ascribed to the HA, NA, M2, NP, and M1 proteins. Only the HA and NA antibodies have been shown to provide immunity in humans. Anti-HA antibody mediates neutralization and serum IgG anti-HA antibody is the dominant antibody in the lower respiratory tract. Since evidence indicates that most infections are acquired by the airborne route with deposition of virus in the lower respiratory tract, serum IgG anti-HA antibody is the primary mediator of immunity to influenza. Homotypic immunity is high for decades. Both antigenic drift and shift of the surface antigens reduce the effectiveness of antibody to the HA and NA and lead to renewed susceptibility to infection. Nevertheless, heterotypic antibody can convey substantial immunity with the degree dependent upon the extent of cross-reactivity for the infecting virus antigens. While serum anti-HA antibody is the major need for optimal immunity to influenza, a full complement of immune modalities is desirable to ensure maximum immunity.
Similar articles
- Immunity to influenza.
Schild GC, Oxford JS, Virelizier JL. Schild GC, et al. Dev Biol Stand. 1975;28:253-72. Dev Biol Stand. 1975. PMID: 47824 - Defense mechanisms against influenza virus infection in the respiratory tract mucosa.
Tamura S, Kurata T. Tamura S, et al. Jpn J Infect Dis. 2004 Dec;57(6):236-47. Jpn J Infect Dis. 2004. PMID: 15623947 Review. - Intranasal immunization with liposome-encapsulated plasmid DNA encoding influenza virus hemagglutinin elicits mucosal, cellular and humoral immune responses.
Wang D, Christopher ME, Nagata LP, Zabielski MA, Li H, Wong JP, Samuel J. Wang D, et al. J Clin Virol. 2004 Dec;31 Suppl 1:S99-106. doi: 10.1016/j.jcv.2004.09.013. J Clin Virol. 2004. PMID: 15567101
Cited by
- Understanding the Role of HLA Class I Molecules in the Immune Response to Influenza Infection and Rational Design of a Peptide-Based Vaccine.
Muraduzzaman AKM, Illing PT, Mifsud NA, Purcell AW. Muraduzzaman AKM, et al. Viruses. 2022 Nov 21;14(11):2578. doi: 10.3390/v14112578. Viruses. 2022. PMID: 36423187 Free PMC article. Review. - Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans.
Richards KA, Moritzky S, Shannon I, Fitzgerald T, Yang H, Branche A, Topham DJ, Treanor JJ, Nayak J, Sant AJ. Richards KA, et al. NPJ Vaccines. 2020 Aug 26;5:77. doi: 10.1038/s41541-020-00227-x. eCollection 2020. NPJ Vaccines. 2020. PMID: 32884842 Free PMC article. - Microgravimetric immunosensor for direct detection of aerosolized influenza A virus particles.
Owen TW, Al-Kaysi RO, Bardeen CJ, Cheng Q. Owen TW, et al. Sens Actuators B Chem. 2007 Oct 1;126(2):691-699. doi: 10.1016/j.snb.2007.04.028. Epub 2007 Apr 24. Sens Actuators B Chem. 2007. PMID: 32288239 Free PMC article. - Immunologic response to vaccine challenge in pregnant PTPN22 R620W carriers and non-carriers.
Tien SH, Crabtree JN, Gray HL, Peterson EJ. Tien SH, et al. PLoS One. 2017 Jul 19;12(7):e0181338. doi: 10.1371/journal.pone.0181338. eCollection 2017. PLoS One. 2017. PMID: 28723925 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Miscellaneous