Protein kinase D and keratinocyte proliferation - PubMed (original) (raw)
Review
Protein kinase D and keratinocyte proliferation
Wendy B Bollag et al. Drug News Perspect. 2004 Mar.
Abstract
Keratinocytes undergo a distinct pattern of proliferation and differentiation that is essential for the function of the skin as a protective barrier. Defects in the equilibrium between proliferation and differentiation compromise the skin's barrier function and give rise to human diseases such as psoriasis and nonmelanoma skin cancer. The identification of protein kinase C (PKC) as a major cellular target for tumor-promoting phorbol esters suggested the involvement of this enzyme in the regulation of keratinocyte proliferation and tumorigenesis; however, results have demonstrated the existence in keratinocytes and other cell types of another diacylglycerol/phorbol ester-responsive protein kinase: protein kinase D (PKD) in mouse, also known as PKC micro in humans. Although numerous data suggest the importance of PKD/PKC micro in processes related to proliferation in many cell types, including keratinocytes, there are no specific inhibitors of PKD currently available. Current treatment strategies for hyperproliferative skin disorders are often suboptimal, either because of lack of efficacy or because of contraindications due to deleterious side effects or aesthetic considerations. Thus, PKD/PKC micro may represent a novel target for the development of new and more efficacious drug treatments for hyperproliferative skin disorders.
Similar articles
- Putative conventional protein kinase C inhibitor Gödecke 6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] stimulates transglutaminase activity in primary mouse epidermal keratinocytes.
Shapiro BA, Ray S, Jung E, Allred WT, Bollag WB. Shapiro BA, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):352-8. doi: 10.1124/jpet.302.1.352. J Pharmacol Exp Ther. 2002. PMID: 12065737 - The potential use of protein kinase D inhibitors for prevention/treatment of epidermal tumors.
Arun SN, Xie D, Dodd ME, Zhong X, Bollag WB. Arun SN, et al. J Dermatol Sci. 2010 Oct;60(1):29-39. doi: 10.1016/j.jdermsci.2010.07.015. Epub 2010 Aug 10. J Dermatol Sci. 2010. PMID: 20832999 Free PMC article. - The involvement of protein kinase C in proliferation and differentiation of human keratinocytes--an investigation using inhibitors of protein kinase C.
Hegemann L, Kempenaar J, Ponec M. Hegemann L, et al. Arch Dermatol Res. 1994;286(5):278-84. doi: 10.1007/BF00387601. Arch Dermatol Res. 1994. PMID: 8060157 - Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms.
Denning MF. Denning MF. Int J Biochem Cell Biol. 2004 Jul;36(7):1141-6. doi: 10.1016/j.biocel.2003.12.004. Int J Biochem Cell Biol. 2004. PMID: 15109560 Review. - Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression.
Isakov N. Isakov N. Semin Cancer Biol. 2018 Feb;48:36-52. doi: 10.1016/j.semcancer.2017.04.012. Epub 2017 May 29. Semin Cancer Biol. 2018. PMID: 28571764 Review.
Cited by
- Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor Snail1.
Eiseler T, Köhler C, Nimmagadda SC, Jamali A, Funk N, Joodi G, Storz P, Seufferlein T. Eiseler T, et al. J Biol Chem. 2012 Sep 21;287(39):32367-80. doi: 10.1074/jbc.M112.370999. Epub 2012 Jul 12. J Biol Chem. 2012. PMID: 22791710 Free PMC article. - Cell wounding activates phospholipase D in primary mouse keratinocytes.
Arun SN, Xie D, Howard AC, Zhong Q, Zhong X, McNeil PL, Bollag WB. Arun SN, et al. J Lipid Res. 2013 Mar;54(3):581-591. doi: 10.1194/jlr.M027060. Epub 2013 Jan 2. J Lipid Res. 2013. PMID: 23288946 Free PMC article. - Exploring Skin Wound Healing Models and the Impact of Natural Lipids on the Healing Process.
Choudhary V, Choudhary M, Bollag WB. Choudhary V, et al. Int J Mol Sci. 2024 Mar 28;25(7):3790. doi: 10.3390/ijms25073790. Int J Mol Sci. 2024. PMID: 38612601 Free PMC article. Review. - Protein kinase D is implicated in the reversible commitment to differentiation in primary cultures of mouse keratinocytes.
Jadali A, Ghazizadeh S. Jadali A, et al. J Biol Chem. 2010 Jul 23;285(30):23387-97. doi: 10.1074/jbc.M110.105619. Epub 2010 May 12. J Biol Chem. 2010. PMID: 20463010 Free PMC article.