Penetrance and expressivity of MSH6 germline mutations in seven kindreds not ascertained by family history - PubMed (original) (raw)

Figure 1

MSH6 kindreds. Kindred 1524, I-1 Hodgkin lymphoma, age 58; I-2 Hodgkin lymphoma, age 44; I-3 lung cancer, age 36; I-4 laryngeal cancer, age 61; I-5 colon cancer, age 92; I-6 endometrial cancer, age 65; II-1 lung cancer, age 69; II-2 prostate cancer, age 73; II-3 colonic tubular adenoma, age 69; II-4 lung cancer, age 74; II-5 lung cancer (small cell), age 71, and lung cancer (oat cell), age 78; III-1 endometrial cancer, age 46; III-2 atypical pituitary adenoma, age 38. Kindred 1401, I-1 colon cancer, age 80; II-1 pancreatic cancer, age 73; II-2 cholangiocarcinoma, age 86; II-3 glioblastoma, age 80s; II-4 uterine cancer, age 40s (unconfirmed), and adenomatous colon polyps, age 86; II-5 renal cell cancer, age 50s (unconfirmed), and breast cancer, age 97; III-1 endometrial cancer, age 57; III-2 basal cell cancer, age 56; III-3 adenomatous colon polyps, age 53; III-4 prostate cancer, age 62, and adenomatous colon polyps, age 66. Kindred 1319, I-1 skin cancer, age 60s; II-1 cancer, unknown primary, age 40s; II-2 cancer, unknown primary, age 61; II-3 cancer, unknown primary, age 40; II-4 cancer, unknown primary, age 60; II-5 multiple myeloma, age 70s; III-1 endometrial cancer, age 40s; III-2 endometrial cancer, age 74; III-3 skin cancer, age 50s. Kindred 1064, II-1 breast cancer, age late 20s; II-2 brain cancer, age 60s; II-3 oat cell lung cancer, age 66; II-4 ovarian cancer, late 30s, and colon cancer, age 40s; II-5 rectal cancer, age 65; III-1 tongue squamous cell carcinoma, age 63; III-2 endometrial cancer, age 53, and rectal cancer, age 61; IV-1 medulloblastoma, age 3. Kindred 1497, I-1 esophageal cancer, age unknown; II-1 endometrial cancer, age 52, and ovarian cancer, age 52. Kindred 1335, I-1 lung cancer, age unknown; I-2 liver cancer, age unknown; I-3 prostate cancer, age 40s; I-4 breast cancer, age 60; I-5 prostate cancer, age 60; I-6 endometrial cancer, age 50s; II-1 pancreatic cancer, age 71; II-2 endometrial cancer, age 35, and colon cancer, age 67; II-3 adenomatous colon polyps, age 65; III-1 endometrial cancer, age 44. Kindred 1389, II-1 endometrial cancer, age 30; III-1 cancer, unknown primary, age unknown; III-2 lung cancer, age 60s; III-3 breast cancer, age 70s; III-4 bladder cancer, age 72; III-5 endometrial cancer, age 61; III-6 cancer, unknown primary, age 76; IV-1 cancer, unknown primary, age unknown.