Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8 - PubMed (original) (raw)
. 2004 Jun 4;304(5676):1500-2.
doi: 10.1126/science.1096645. Epub 2004 May 6.
Affiliations
- PMID: 15131264
- DOI: 10.1126/science.1096645
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
Li Yu et al. Science. 2004.
Abstract
Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially involving necrosis and autophagy may exist, but their relation to apoptosis and mechanisms of regulation remains unclear. We define a new molecular pathway in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy. Autophagic death required the genes ATG7 and beclin 1 and was induced by caspase-8 inhibition. Clinical therapies involving caspase inhibitors may arrest apoptosis but also have the unanticipated effect of promoting autophagic cell death.
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