The stalk region of dynamin drives the constriction of dynamin tubes - PubMed (original) (raw)

doi: 10.1038/nsmb762. Epub 2004 May 9.

Affiliations

• PMID: 15133500
• DOI: 10.1038/nsmb762

The stalk region of dynamin drives the constriction of dynamin tubes

Yen-Ju Chen et al. Nat Struct Mol Biol. 2004 Jun.

Abstract

The GTPase dynamin is essential for numerous vesiculation events including clathrin-mediated endocytosis. Upon GTP hydrolysis, dynamin constricts a lipid bilayer. Previously, a three-dimensional structure of mutant dynamin in the constricted state was determined by helical reconstruction methods. We solved the nonconstricted state by a single-particle approach and show that the stalk region of dynamin undergoes a large conformational change that drives tube constriction.

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