Nonsense-mediated mRNA decay: terminating erroneous gene expression - PubMed (original) (raw)
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Nonsense-mediated mRNA decay: terminating erroneous gene expression
Kristian E Baker et al. Curr Opin Cell Biol. 2004 Jun.
Abstract
Nonsense-mediated mRNA decay is a surveillance pathway that reduces errors in gene expression by eliminating aberrant mRNAs that encode incomplete polypeptides. Recent experiments suggest a working model whereby premature and normal translation termination events are distinct as a consequence of the spatial relationship between the termination codon and mRNA binding proteins, a relationship partially established by nuclear pre-mRNA processing. Aberrant termination then leads to both translational repression and an increased susceptibility of the mRNA to multiple ribonucleases.
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