Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness - PubMed (original) (raw)
doi: 10.1038/ncb1131. Epub 2004 May 16.
Takashi Sakurai, Jean K Stewart, Dean Yimlamai, Christine Unger, Carol Zehetmeier, Blanca Lain, Claudia Torella, Stefan W Henning, Gerald Beste, Bradley T Scroggins, Len Neckers, Leodevico L Ilag, Daniel G Jay
Affiliations
- PMID: 15146192
- DOI: 10.1038/ncb1131
Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness
Brenda K Eustace et al. Nat Cell Biol. 2004 Jun.
Abstract
Tumour cell invasiveness is crucial for cancer metastasis and is not yet understood. Here we describe two functional screens for proteins required for the invasion of fibrosarcoma cells that identified the molecular chaperone heat shock protein 90 (hsp90). The hsp90 alpha isoform, but not hsp90 beta, is expressed extracellularly where it interacts with the matrix metalloproteinase 2 (MMP2). Inhibition of extracellular hsp90 alpha decreases both MMP2 activity and invasiveness. This role for extracellular hsp90 alpha in MMP2 activation indicates that cell-impermeant anti-hsp90 drugs might decrease invasiveness without the concerns inherent in inhibiting intracellular hsp90.
Comment in
- Hsp90 invades the outside.
Picard D. Picard D. Nat Cell Biol. 2004 Jun;6(6):479-80. doi: 10.1038/ncb0604-479. Nat Cell Biol. 2004. PMID: 15170457
Similar articles
- Hsp90 invades the outside.
Picard D. Picard D. Nat Cell Biol. 2004 Jun;6(6):479-80. doi: 10.1038/ncb0604-479. Nat Cell Biol. 2004. PMID: 15170457 - Extracellular roles for the molecular chaperone, hsp90.
Eustace BK, Jay DG. Eustace BK, et al. Cell Cycle. 2004 Sep;3(9):1098-100. Epub 2004 Sep 14. Cell Cycle. 2004. PMID: 15326368 Review. - Inhibition of cancer invasion and metastasis by targeting the molecular chaperone heat-shock protein 90.
Koga F, Kihara K, Neckers L. Koga F, et al. Anticancer Res. 2009 Mar;29(3):797-807. Anticancer Res. 2009. PMID: 19414312 Review.
Cited by
- Molecularly targeted agents as radiosensitizers in cancer therapy--focus on prostate cancer.
Alcorn S, Walker AJ, Gandhi N, Narang A, Wild AT, Hales RK, Herman JM, Song DY, Deweese TL, Antonarakis ES, Tran PT. Alcorn S, et al. Int J Mol Sci. 2013 Jul 16;14(7):14800-32. doi: 10.3390/ijms140714800. Int J Mol Sci. 2013. PMID: 23863691 Free PMC article. Review. - Regulation of survival and chemoresistance by HSP90AA1 in ovarian cancer SKOV3 cells.
Chu SH, Liu YW, Zhang L, Liu B, Li L, Shi JZ, Li L. Chu SH, et al. Mol Biol Rep. 2013 Jan;40(1):1-6. doi: 10.1007/s11033-012-1930-3. Epub 2012 Nov 8. Mol Biol Rep. 2013. PMID: 23135731 - A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α-positive tumors.
Sahu D, Zhao Z, Tsen F, Cheng CF, Park R, Situ AJ, Dai J, Eginli A, Shams S, Chen M, Ulmer TS, Conti P, Woodley DT, Li W. Sahu D, et al. Mol Biol Cell. 2012 Feb;23(4):602-13. doi: 10.1091/mbc.E11-06-0575. Epub 2011 Dec 21. Mol Biol Cell. 2012. PMID: 22190738 Free PMC article. - Prion protein binding to HOP modulates the migration and invasion of colorectal cancer cells.
de Lacerda TC, Costa-Silva B, Giudice FS, Dias MV, de Oliveira GP, Teixeira BL, Dos Santos TG, Martins VR. de Lacerda TC, et al. Clin Exp Metastasis. 2016 Jun;33(5):441-51. doi: 10.1007/s10585-016-9788-8. Epub 2016 Apr 25. Clin Exp Metastasis. 2016. PMID: 27112151 - The Distinct Assignments for Hsp90α and Hsp90β: More Than Skin Deep.
Chang C, Tang X, Woodley DT, Chen M, Li W. Chang C, et al. Cells. 2023 Jan 11;12(2):277. doi: 10.3390/cells12020277. Cells. 2023. PMID: 36672211 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous