The amygdala and persistent pain - PubMed (original) (raw)
Review
The amygdala and persistent pain
Volker Neugebauer et al. Neuroscientist. 2004 Jun.
Abstract
A reciprocal relationship exists between persistent pain and negative affective states such as fear, anxiety, and depression. Accumulating evidence points to the amygdala as an important site of such interaction. Whereas a key role of the amygdala in the neuronal mechanisms of emotionality and affective disorders has been well established, the concept of the amygdala as an important contributor to pain and its emotional component is still emerging. This article will review and discuss evidence from anatomical, neuroimaging, behavioral, electrophysiological, pharmacological, and biochemical data that implicate the amygdala in pain modulation and emotional responses to pain. The latero-capsular division of the central nucleus of the amygdala is now defined as the "nociceptive amygdala" and integrates nociceptive information with poly-modal information about the internal and external bodily environment. Dependent on environmental conditions and affective states, the amygdala appears to play a dual facilitatory and inhibitory role in the modulation of pain behavior and nociceptive processing at different levels of the pain neuraxis. Only recently, electrophysiological, pharmacological, and biochemical neuroplastic changes were shown in the nociceptive amygdala in persistent pain. It is conceivable, however, that amygdala plasticity plays an important role in emotional pain behavior and its modulation by affective state.
Similar articles
- Synaptic plasticity in the amygdala in a visceral pain model in rats.
Han JS, Neugebauer V. Han JS, et al. Neurosci Lett. 2004 May 6;361(1-3):254-7. doi: 10.1016/j.neulet.2003.12.027. Neurosci Lett. 2004. PMID: 15135941 - [Involvement of amygdala in the emotional processing of pain].
Huang J, Kang XZ, Luo P. Huang J, et al. Sheng Li Ke Xue Jin Zhan. 2005 Oct;36(4):289-94. Sheng Li Ke Xue Jin Zhan. 2005. PMID: 16408764 Review. Chinese. - The amygdala, the hippocampus, and emotional modulation of memory.
Richter-Levin G. Richter-Levin G. Neuroscientist. 2004 Feb;10(1):31-9. doi: 10.1177/1073858403259955. Neuroscientist. 2004. PMID: 14987446 Review. - Neuronal mechanisms for pain-induced aversion behavioral studies using a conditioned place aversion test.
Minami M. Minami M. Int Rev Neurobiol. 2009;85:135-44. doi: 10.1016/S0074-7742(09)85010-1. Int Rev Neurobiol. 2009. PMID: 19607966 Review. - Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety.
Shekhar A, Truitt W, Rainnie D, Sajdyk T. Shekhar A, et al. Stress. 2005 Dec;8(4):209-19. doi: 10.1080/10253890500504557. Stress. 2005. PMID: 16423710 Review.
Cited by
- Pain in Parkinson's disease: a neuroanatomy-based approach.
Nardelli D, Gambioli F, De Bartolo MI, Mancinelli R, Biagioni F, Carotti S, Falato E, Leodori G, Puglisi-Allegra S, Vivacqua G, Fornai F. Nardelli D, et al. Brain Commun. 2024 Jun 18;6(4):fcae210. doi: 10.1093/braincomms/fcae210. eCollection 2024. Brain Commun. 2024. PMID: 39130512 Free PMC article. Review. - Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception.
Dou YN, Liu Y, Ding WQ, Li Q, Zhou H, Li L, Zhao MT, Li ZY, Yuan J, Wang XF, Zou WY, Li A, Sun YG. Dou YN, et al. Natl Sci Rev. 2024 Jun 4;11(7):nwae195. doi: 10.1093/nsr/nwae195. eCollection 2024 Jul. Natl Sci Rev. 2024. PMID: 39045468 Free PMC article. - Ionic mechanisms involved in arginine vasopressin-mediated excitation of auditory cortical and thalamic neurons.
Kola PK, Oraegbuna CS, Lei S. Kola PK, et al. Mol Cell Neurosci. 2024 Sep;130:103951. doi: 10.1016/j.mcn.2024.103951. Epub 2024 Jun 26. Mol Cell Neurosci. 2024. PMID: 38942186 - Dysfunction of Small-Conductance Ca2+-Activated Potassium (SK) Channels Drives Amygdala Hyperexcitability and Neuropathic Pain Behaviors: Involvement of Epigenetic Mechanisms.
Yakhnitsa V, Thompson J, Ponomareva O, Ji G, Kiritoshi T, Mahimainathan L, Molehin D, Pruitt K, Neugebauer V. Yakhnitsa V, et al. Cells. 2024 Jun 18;13(12):1055. doi: 10.3390/cells13121055. Cells. 2024. PMID: 38920682 Free PMC article. - Distinct eLPBChAT projections for methamphetamine withdrawal anxiety and primed reinstatement of conditioned place preference.
Chen W, Guo H, Zhou N, Mai Y, Hu T, Xu X, He T, Wen J, Qin S, Liu C, Wu W, Kim HY, Fan Y, Ge F, Guan X. Chen W, et al. Theranostics. 2024 Apr 29;14(7):2881-2896. doi: 10.7150/thno.95383. eCollection 2024. Theranostics. 2024. PMID: 38773977 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources