Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression - PubMed (original) (raw)

Review

. 2004 May 24;23(24):4315-29.

doi: 10.1038/sj.onc.1207676.

Affiliations

• PMID: 15156188
• DOI: 10.1038/sj.onc.1207676

Review

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Gary S Stein et al. Oncogene. 2004.

Abstract

We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

PubMed Disclaimer

Similar articles

• Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors.
  Lian JB, Javed A, Zaidi SK, Lengner C, Montecino M, van Wijnen AJ, Stein JL, Stein GS. Lian JB, et al. Crit Rev Eukaryot Gene Expr. 2004;14(1-2):1-41. Crit Rev Eukaryot Gene Expr. 2004. PMID: 15104525 Review.
• Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins.
  Miyazono K, Maeda S, Imamura T. Miyazono K, et al. Oncogene. 2004 May 24;23(24):4232-7. doi: 10.1038/sj.onc.1207131. Oncogene. 2004. PMID: 15156178 Review.
• Structure and regulated expression of mammalian RUNX genes.
  Levanon D, Groner Y. Levanon D, et al. Oncogene. 2004 May 24;23(24):4211-9. doi: 10.1038/sj.onc.1207670. Oncogene. 2004. PMID: 15156175 Review.
• Oncogenic potential of the RUNX gene family: 'overview'.
  Ito Y. Ito Y. Oncogene. 2004 May 24;23(24):4198-208. doi: 10.1038/sj.onc.1207755. Oncogene. 2004. PMID: 15156173 Review.
• Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals.
  Stein GS, Stein JL, Lian JB, Van Wijnen AJ, Montecino M, Javed A, Zaidi SK, Young D, Choi JY, Pockwinse S. Stein GS, et al. Eur J Histochem. 2004;48(1):65-76. Eur J Histochem. 2004. PMID: 15145777 Review.

Cited by

• Hypoxia-inducible factor 2α is a novel inhibitor of chondrocyte maturation.
  Che X, Park NR, Jin X, Jung YK, Han MS, Park CY, Chun JS, Kim SG, Jin J, Kim HJ, Lian JB, Stein JL, Stein GS, Choi JY. Che X, et al. J Cell Physiol. 2021 Oct;236(10):6963-6973. doi: 10.1002/jcp.30356. Epub 2021 Mar 21. J Cell Physiol. 2021. PMID: 33748969 Free PMC article.
• Surface Free Energy Dominates the Biological Interactions of Postprocessed Additively Manufactured Ti-6Al-4V.
  Villapun Puzas VM, Carter LN, Schröder C, Colavita PE, Hoey DA, Webber MA, Addison O, Shepherd DET, Attallah MM, Grover LM, Cox SC. Villapun Puzas VM, et al. ACS Biomater Sci Eng. 2022 Oct 10;8(10):4311-4326. doi: 10.1021/acsbiomaterials.2c00298. Epub 2022 Sep 20. ACS Biomater Sci Eng. 2022. PMID: 36127820 Free PMC article.
• Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptor.
  Yun HM, Park KR, Hong JT, Kim EC. Yun HM, et al. Sci Rep. 2016 Sep 1;6:30985. doi: 10.1038/srep30985. Sci Rep. 2016. PMID: 27581523 Free PMC article.
• Effects of anti-tumor necrosis factor α agents on bone.
  Kawai VK, Stein CM, Perrien DS, Griffin MR. Kawai VK, et al. Curr Opin Rheumatol. 2012 Sep;24(5):576-85. doi: 10.1097/BOR.0b013e328356d212. Curr Opin Rheumatol. 2012. PMID: 22810364 Free PMC article. Review.
• The Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton's Jelly Stem Cells.
  Ma L, He X, Wu Q. Ma L, et al. Int J Mol Sci. 2023 Aug 18;24(16):12909. doi: 10.3390/ijms241612909. Int J Mol Sci. 2023. PMID: 37629090 Free PMC article. Review.

Publication types

MeSH terms

Substances

Grants and funding

• DE12528/DE/NIDCR NIH HHS/United States
• AR45689/AR/NIAMS NIH HHS/United States
• AR39588/AR/NIAMS NIH HHS/United States
• P01CA82834/CA/NCI NIH HHS/United States
• R01 AR049069/AR/NIAMS NIH HHS/United States
• AR45688/AR/NIAMS NIH HHS/United States
• P01AR48818/AR/NIAMS NIH HHS/United States
• R03 TW00990/TW/FIC NIH HHS/United States

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database