An active and socially integrated lifestyle in late life might protect against dementia - PubMed (original) (raw)
Review
An active and socially integrated lifestyle in late life might protect against dementia
Laura Fratiglioni et al. Lancet Neurol. 2004 Jun.
Abstract
The recent availability of longitudinal data on the possible association of different lifestyles with dementia and Alzheimer's disease (AD) allow some preliminary conclusions on this topic. This review systematically analyses the published longitudinal studies exploring the effect of social network, physical leisure, and non-physical activity on cognition and dementia and then summarises the current evidence taking into account the limitations of the studies and the biological plausibility. For all three lifestyle components (social, mental, and physical), a beneficial effect on cognition and a protective effect against dementia are suggested. The three components seem to have common pathways, rather than specific mechanisms, which might converge within three major aetiological hypotheses for dementia and AD: the cognitive reserve hypothesis, the vascular hypothesis, and the stress hypothesis. Taking into account the accumulated evidence and the biological plausibility of these hypotheses, we conclude that an active and socially integrated lifestyle in late life protects against dementia and AD. Further research is necessary to better define the mechanisms of these associations and better delineate preventive and therapeutic strategies.
Similar articles
- Leisure activities, cognition and dementia.
Wang HX, Xu W, Pei JJ. Wang HX, et al. Biochim Biophys Acta. 2012 Mar;1822(3):482-91. doi: 10.1016/j.bbadis.2011.09.002. Epub 2011 Sep 10. Biochim Biophys Acta. 2012. PMID: 21930203 Review. - Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease.
Rovio S, Kåreholt I, Helkala EL, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M. Rovio S, et al. Lancet Neurol. 2005 Nov;4(11):705-11. doi: 10.1016/S1474-4422(05)70198-8. Lancet Neurol. 2005. PMID: 16239176 Clinical Trial. - Prevention of Alzheimer's disease and dementia. Major findings from the Kungsholmen Project.
Fratiglioni L, Winblad B, von Strauss E. Fratiglioni L, et al. Physiol Behav. 2007 Sep 10;92(1-2):98-104. doi: 10.1016/j.physbeh.2007.05.059. Epub 2007 May 25. Physiol Behav. 2007. PMID: 17588621 Review. - Diet and Alzheimer's disease risk factors or prevention: the current evidence.
Solfrizzi V, Panza F, Frisardi V, Seripa D, Logroscino G, Imbimbo BP, Pilotto A. Solfrizzi V, et al. Expert Rev Neurother. 2011 May;11(5):677-708. doi: 10.1586/ern.11.56. Expert Rev Neurother. 2011. PMID: 21539488 Review. - Lifestyle-related factors in predementia and dementia syndromes.
Solfrizzi V, Capurso C, D'Introno A, Colacicco AM, Santamato A, Ranieri M, Fiore P, Capurso A, Panza F. Solfrizzi V, et al. Expert Rev Neurother. 2008 Jan;8(1):133-58. doi: 10.1586/14737175.8.1.133. Expert Rev Neurother. 2008. PMID: 18088206 Review.
Cited by
- The unique and synergistic effects of social isolation and loneliness on 20-years mortality risks in older men and women.
Aartsen M, Vangen H, Pavlidis G, Hansen T, Precupetu I. Aartsen M, et al. Front Public Health. 2024 Oct 16;12:1432701. doi: 10.3389/fpubh.2024.1432701. eCollection 2024. Front Public Health. 2024. PMID: 39478752 Free PMC article. - Swimming as a positive moderator of cognitive aging: a cross-sectional study with a multitask approach.
Abou-Dest A, Albinet CT, Boucard G, Audiffren M. Abou-Dest A, et al. J Aging Res. 2012;2012:273185. doi: 10.1155/2012/273185. Epub 2012 Dec 26. J Aging Res. 2012. PMID: 23326664 Free PMC article. - A review of cardiorespiratory fitness-related neuroplasticity in the aging brain.
Hayes SM, Hayes JP, Cadden M, Verfaellie M. Hayes SM, et al. Front Aging Neurosci. 2013 Jul 12;5:31. doi: 10.3389/fnagi.2013.00031. eCollection 2013. Front Aging Neurosci. 2013. PMID: 23874299 Free PMC article. - Musical and Multilingual Experience Are Related to Healthy Aging: Better Some Than None But Even Better Together.
Nijmeijer SE, van Tol MJ, Aleman A, Keijzer M. Nijmeijer SE, et al. J Gerontol B Psychol Sci Soc Sci. 2023 Apr 1;78(4):609-619. doi: 10.1093/geronb/gbac185. J Gerontol B Psychol Sci Soc Sci. 2023. PMID: 36454717 Free PMC article. - The MEDITAGING study: protocol of a two-armed randomized controlled study to compare the effects of the mindfulness-based stress reduction program against a health promotion program in older migrants in Luxembourg.
Teixeira-Santos AC, Gomes L, Pereira DR, Ribeiro F, Silva-Fernandes A, Federspiel C, Steinmetz JP, Leist AK. Teixeira-Santos AC, et al. BMC Public Health. 2023 Dec 11;23(1):2470. doi: 10.1186/s12889-023-17387-9. BMC Public Health. 2023. PMID: 38082350 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical