The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development - PubMed (original) (raw)
The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development
A G Bang et al. Genes Dev. 1992 Sep.
Free article
Erratum in
- Genes Dev 1992 Nov;6(11):2233
Abstract
The mechanosensory bristles of adult Drosophila are composed of four cells that, in most cases, are progeny of a single sensory organ precursor (SOP) cell. Two sister cells in this lineage, the trichogen and tormogen, produce the external shaft and socket of the bristle, respectively. Loss-of-function mutations of Hairless (H) confer two distinct mutant phenotypes on adult bristles. The bristle loss phenotype results from the failure to specify and/or execute the SOP cell fate; the double socket phenotype results from the transformation of the trichogen (shaft) cell into a second tormogen (socket) cell. We have found that the H gene encodes a novel basic protein with a predicted molecular mass of 109 kD. Basal levels of expression of a transgene (P[Hs-H]) in which the H protein-coding region is under the control of the Hsp70 promoter are sufficient to provide full rescue of H mutant phenotypes. Heat shock treatment of P[Hs-H] transgenic animals as late larvae and early pupae produces a tormogen-to-trichogen (double shaft) cell fate transformation, as well as bristle multiplication and loss phenotypes very similar to those caused by loss-of-function mutations in the neurogenic gene Notch. Our results indicate that the SOP cell fate requires H to antagonize the activity of the neurogenic group of genes and that the expression of distinct cell fates by the trichogen/tormogen sister cell pair depends on an asymmetry in their levels of H+ activity or in their thresholds for response to H.
Similar articles
- Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis.
Schweisguth F, Posakony JW. Schweisguth F, et al. Development. 1994 Jun;120(6):1433-41. doi: 10.1242/dev.120.6.1433. Development. 1994. PMID: 8050354 - Gain-of-function alleles of Bearded interfere with alternative cell fate decisions in Drosophila adult sensory organ development.
Leviten MW, Posakony JW. Leviten MW, et al. Dev Biol. 1996 Jun 15;176(2):264-83. doi: 10.1006/dbio.1996.0133. Dev Biol. 1996. PMID: 8660866 - Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development.
Lyman DF, Yedvobnick B. Lyman DF, et al. Genetics. 1995 Dec;141(4):1491-505. doi: 10.1093/genetics/141.4.1491. Genetics. 1995. PMID: 8601489 Free PMC article. - Morphogenesis of Drosophila melanogaster macrochaetes: cell fate determination for bristle organ.
Furman DP, Bukharina TA. Furman DP, et al. J Stem Cells. 2012;7(1):19-41. J Stem Cells. 2012. PMID: 23550342 Review. - Robust selection of sensory organ precursors by the Notch-Delta pathway.
Barad O, Hornstein E, Barkai N. Barad O, et al. Curr Opin Cell Biol. 2011 Dec;23(6):663-7. doi: 10.1016/j.ceb.2011.09.005. Epub 2011 Sep 29. Curr Opin Cell Biol. 2011. PMID: 21963301 Review.
Cited by
- Novel Genome-Engineered H Alleles Differentially Affect Lateral Inhibition and Cell Dichotomy Processes during Bristle Organ Development.
Mönch TC, Smylla TK, Brändle F, Preiss A, Nagel AC. Mönch TC, et al. Genes (Basel). 2024 Apr 26;15(5):552. doi: 10.3390/genes15050552. Genes (Basel). 2024. PMID: 38790181 Free PMC article. - Co-option of epidermal cells enables touch sensing.
Mangione F, Titlow J, Maclachlan C, Gho M, Davis I, Collinson L, Tapon N. Mangione F, et al. Nat Cell Biol. 2023 Apr;25(4):540-549. doi: 10.1038/s41556-023-01110-2. Epub 2023 Mar 23. Nat Cell Biol. 2023. PMID: 36959505 Free PMC article. - Genetic and Molecular Interactions between H_Δ_CT, a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster.
Maier D, Bauer M, Boger M, Sanchez Jimenez A, Yuan Z, Fechner J, Scharpf J, Kovall RA, Preiss A, Nagel AC. Maier D, et al. Genes (Basel). 2023 Jan 13;14(1):205. doi: 10.3390/genes14010205. Genes (Basel). 2023. PMID: 36672946 Free PMC article. - Temperature-Inducible Precision-Guided Sterile Insect Technique.
Kandul NP, Liu J, Akbari OS. Kandul NP, et al. CRISPR J. 2021 Dec;4(6):822-835. doi: 10.1089/crispr.2021.0077. Epub 2021 Nov 3. CRISPR J. 2021. PMID: 34735288 Free PMC article. - Desensitisation of Notch signalling through dynamic adaptation in the nucleus.
Viswanathan R, Hartmann J, Pallares Cartes C, De Renzis S. Viswanathan R, et al. EMBO J. 2021 Sep 15;40(18):e107245. doi: 10.15252/embj.2020107245. Epub 2021 Aug 16. EMBO J. 2021. PMID: 34396565 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases