An angiogenic switch in breast cancer involves estrogen and soluble vascular endothelial growth factor receptor 1 - PubMed (original) (raw)
. 2004 Jun 2;96(11):875-8.
doi: 10.1093/jnci/djh140.
Affiliations
- PMID: 15173272
- DOI: 10.1093/jnci/djh140
An angiogenic switch in breast cancer involves estrogen and soluble vascular endothelial growth factor receptor 1
Michael Elkin et al. J Natl Cancer Inst. 2004.
Abstract
Estrogen is involved in breast tumorigenesis, but the precise mechanisms for its oncogenic and angiogenic actions are poorly understood. Angiogenesis is regulated, in part, by these critical components: vascular endothelial growth factor (VEGF) and its two receptors (VEGFR-1 and VEGFR-2). VEGFR-2 is a positive angiogenic signal transducer, whereas VEGFR-1, especially its soluble form (soluble VEGFR-1), is a negative regulator of VEGF availability. We found that breast epithelial cells express soluble VEGFR-1 and hypothesized that because estrogen can regulate expression of members of the VEGF family, it might stimulate angiogenesis in breast cancer by decreasing expression of soluble VEGFR-1. Soluble VEGFR-1 expression decreased in estrogen receptor (ER)-positive but not in ER-negative breast cancer cell lines treated with estrogen. Pretreatment of the cells with the ER antagonist ICI 182,780 blocked the effect. The estrogen-mediated decrease in soluble VEGFR-1 expression was accompanied by a statistically significant increase in angiogenesis in vivo. Our data suggest that inhibition of soluble VEGFR-1 expression represents a novel mechanism--an estrogen-driven angiogenic switch--possibly responsible for breast carcinoma progression.
Similar articles
- Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines.
Simiantonaki N, Jayasinghe C, Michel-Schmidt R, Peters K, Hermanns MI, Kirkpatrick CJ. Simiantonaki N, et al. Int J Oncol. 2008 Mar;32(3):585-92. Int J Oncol. 2008. PMID: 18292935 - Positive and Negative Regulation of Angiogenesis by Soluble Vascular Endothelial Growth Factor Receptor-1.
Failla CM, Carbo M, Morea V. Failla CM, et al. Int J Mol Sci. 2018 Apr 27;19(5):1306. doi: 10.3390/ijms19051306. Int J Mol Sci. 2018. PMID: 29702562 Free PMC article. Review. - Intracranial meningiomas, the VEGF-A pathway, and peritumoral brain oedema.
Nassehi D. Nassehi D. Dan Med J. 2013 Apr;60(4):B4626. Dan Med J. 2013. PMID: 23651727 Review.
Cited by
- 17-β Estradiol up-regulates energy metabolic pathways, cellular proliferation and tumor invasiveness in ER+ breast cancer spheroids.
Pacheco-Velázquez SC, Ortega-Mejía II, Vargas-Navarro JL, Padilla-Flores JA, Robledo-Cadena DX, Tapia-Martínez G, Peñalosa-Castro I, Aguilar-Ponce JL, Granados-Rivas JC, Moreno-Sánchez R, Rodríguez-Enríquez S. Pacheco-Velázquez SC, et al. Front Oncol. 2022 Nov 7;12:1018137. doi: 10.3389/fonc.2022.1018137. eCollection 2022. Front Oncol. 2022. PMID: 36419896 Free PMC article. - Macrophages Upregulate Estrogen Receptor Expression in the Model of Obesity-Associated Breast Carcinoma.
Nahmias Blank D, Hermano E, Sonnenblick A, Maimon O, Rubinstein AM, Drai E, Maly B, Vlodavsky I, Popovtzer A, Peretz T, Meirovitz A, Elkin M. Nahmias Blank D, et al. Cells. 2022 Sep 12;11(18):2844. doi: 10.3390/cells11182844. Cells. 2022. PMID: 36139419 Free PMC article. - Multicenter phase II study of apatinib single or combination therapy in HER2-negative breast cancer involving chest wall metastasis.
Li H, Geng C, Zhao H, Jiang H, Song G, Zhang J, Liu Y, Gui X, Wang J, Li K, Tong Z, Zhao F, Yang J, Chen G, Liu Q, Liang X. Li H, et al. Chin J Cancer Res. 2021 Apr 30;33(2):243-255. doi: 10.21147/j.issn.1000-9604.2021.02.11. Chin J Cancer Res. 2021. PMID: 34158743 Free PMC article. - Network analysis of the left anterior descending coronary arteries in swim-trained rats by an in situ video microscopic technique.
Török M, Merkely P, Monori-Kiss A, Horváth EM, Sziva RE, Péterffy B, Jósvai A, Sayour AA, Oláh A, Radovits T, Merkely B, Ács N, Nádasy GL, Várbíró S. Török M, et al. Biol Sex Differ. 2021 May 26;12(1):37. doi: 10.1186/s13293-021-00379-y. Biol Sex Differ. 2021. PMID: 34039432 Free PMC article. - Gemcitabine potentiates anti-tumor effect of resveratrol on pancreatic cancer via down-regulation of VEGF-B.
Yang Y, Tian W, Yang L, Zhang Q, Zhu M, Liu Y, Li J, Yang L, Liu J, Shen Y, Qi Z. Yang Y, et al. J Cancer Res Clin Oncol. 2021 Jan;147(1):93-103. doi: 10.1007/s00432-020-03384-7. Epub 2020 Sep 8. J Cancer Res Clin Oncol. 2021. PMID: 32897433
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical