TAHRE, a novel telomeric retrotransposon from Drosophila melanogaster, reveals the origin of Drosophila telomeres - PubMed (original) (raw)
TAHRE, a novel telomeric retrotransposon from Drosophila melanogaster, reveals the origin of Drosophila telomeres
José P Abad et al. Mol Biol Evol. 2004 Sep.
Abstract
Drosophila telomeres do not have typical telomerase repeats. Instead, two families of non-LTR retrotransposons, HeT-A and TART, maintain telomere length by occasional transposition to the chromosome ends. Despite the work on Drosophila telomeres, its evolutionary origin remains controversial. Herein we describe a novel telomere-specific retroelement that we name TAHRE (Telomere-Associated and HeT-A-Related Element). The structure of the three telomere-specific elements indicates a common ancestor. These results suggest that preexisting transposable elements were recruited to perform the cellular function of telomere maintenance. A recruitment similar to that of a retrotransposal reverse transcriptase has been suggested as the common origin of telomerases.
Similar articles
- Characterization of Drosophila telomeric retroelement TAHRE: transcription, transpositions, and RNAi-based regulation of expression.
Shpiz S, Kwon D, Uneva A, Kim M, Klenov M, Rozovsky Y, Georgiev P, Savitsky M, Kalmykova A. Shpiz S, et al. Mol Biol Evol. 2007 Nov;24(11):2535-45. doi: 10.1093/molbev/msm205. Epub 2007 Sep 21. Mol Biol Evol. 2007. PMID: 17890237 - Drosophila telomeres: two transposable elements with important roles in chromosomes.
Pardue ML, DeBaryshe PG. Pardue ML, et al. Genetica. 1999;107(1-3):189-96. Genetica. 1999. PMID: 10952212 - Drosophila telomeric retrotransposons derived from an ancestral element that was recruited to replace telomerase.
Villasante A, Abad JP, Planelló R, Méndez-Lago M, Celniker SE, de Pablos B. Villasante A, et al. Genome Res. 2007 Dec;17(12):1909-18. doi: 10.1101/gr.6365107. Epub 2007 Nov 7. Genome Res. 2007. PMID: 17989257 Free PMC article. - Drosophila telomeres: an example of co-evolution with transposable elements.
Silva-Sousa R, López-Panadѐs E, Casacuberta E. Silva-Sousa R, et al. Genome Dyn. 2012;7:46-67. doi: 10.1159/000337127. Epub 2012 Jun 25. Genome Dyn. 2012. PMID: 22759813 Review. - Drosophila: Retrotransposons Making up Telomeres.
Casacuberta E. Casacuberta E. Viruses. 2017 Jul 19;9(7):192. doi: 10.3390/v9070192. Viruses. 2017. PMID: 28753967 Free PMC article. Review.
Cited by
- TeloBase: a community-curated database of telomere sequences across the tree of life.
Lyčka M, Bubeník M, Závodník M, Peska V, Fajkus P, Demko M, Fajkus J, Fojtová M. Lyčka M, et al. Nucleic Acids Res. 2024 Jan 5;52(D1):D311-D321. doi: 10.1093/nar/gkad672. Nucleic Acids Res. 2024. PMID: 37602392 Free PMC article. - Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells.
Sung S, Kim E, Niida H, Kim C, Lee J. Sung S, et al. Nucleic Acids Res. 2023 Sep 22;51(17):9122-9143. doi: 10.1093/nar/gkad617. Nucleic Acids Res. 2023. PMID: 37496110 Free PMC article. - The NSL complex is required for piRNA production from telomeric clusters.
Iyer SS, Sun Y, Seyfferth J, Manjunath V, Samata M, Alexiadis A, Kulkarni T, Gutierrez N, Georgiev P, Shvedunova M, Akhtar A. Iyer SS, et al. Life Sci Alliance. 2023 Jun 30;6(9):e202302194. doi: 10.26508/lsa.202302194. Print 2023 Sep. Life Sci Alliance. 2023. PMID: 37399316 Free PMC article. - Mod(mdg4) variants repress telomeric retrotransposon HeT-A by blocking subtelomeric enhancers.
Takeuchi C, Yokoshi M, Kondo S, Shibuya A, Saito K, Fukaya T, Siomi H, Iwasaki YW. Takeuchi C, et al. Nucleic Acids Res. 2022 Nov 11;50(20):11580-11599. doi: 10.1093/nar/gkac1034. Nucleic Acids Res. 2022. PMID: 36373634 Free PMC article. - Telomeres and Their Neighbors.
Jenner LP, Peska V, Fulnečková J, Sýkorová E. Jenner LP, et al. Genes (Basel). 2022 Sep 16;13(9):1663. doi: 10.3390/genes13091663. Genes (Basel). 2022. PMID: 36140830 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources