Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways - PubMed (original) (raw)
Review
. 2004 Apr 30;17(2):188-202.
Affiliations
- PMID: 15179030
Free article
Review
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways
Jung Weon Lee et al. Mol Cells. 2004.
Free article
Abstract
Engagement of cells with the extracellular matrix (ECM) proteins is crucial for various biological processes, including cell adhesion, spreading, proliferation, differentiation, migration, apoptosis, and gene induction, contributing to maintenance of tissue integrity, embryogenesis, wound healing, and the metastasis of tumor cells (Hynes, 2002b; Juliano, 2002). The engagement involves cell adhesion mediated by integrins, a large family of cell adhesion receptors that are transmembrane glycoproteins which bind to ECM or to counter-receptors on neighbor cells. In this review, the molecular basis of signaling mediated by integrins and their collaboration with growth factor receptors will be discussed, based on recent observations. Although other cell adhesion receptors including cadherins, selectins, syndecans, and the immunoglobulin superfamily of cell adhesion molecules (IgCAMs) can play important roles or be involved in these processes, we suggest readers refer to recent outstanding reviews on them (Barclay, 2003; Brummendorf and Lemmon 2001; Panicker et al. 2003).
Similar articles
- Signalling by adhesion receptors.
Fashena SJ, Thomas SM. Fashena SJ, et al. Nat Cell Biol. 2000 Dec;2(12):E225-9. doi: 10.1038/35046654. Nat Cell Biol. 2000. PMID: 11146674 - Syndecans - key regulators of cell signaling and biological functions.
Afratis NA, Nikitovic D, Multhaupt HA, Theocharis AD, Couchman JR, Karamanos NK. Afratis NA, et al. FEBS J. 2017 Jan;284(1):27-41. doi: 10.1111/febs.13940. Epub 2016 Nov 18. FEBS J. 2017. PMID: 27790852 Review. - Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling.
Bass MD, Humphries MJ. Bass MD, et al. Biochem J. 2002 Nov 15;368(Pt 1):1-15. doi: 10.1042/BJ20021228. Biochem J. 2002. PMID: 12241528 Free PMC article. Review. - Integrins in cell adhesion and signaling.
Akiyama SK. Akiyama SK. Hum Cell. 1996 Sep;9(3):181-6. Hum Cell. 1996. PMID: 9183647 Review. - New aspects of integrin signaling in cancer.
Parise LV, Lee J, Juliano RL. Parise LV, et al. Semin Cancer Biol. 2000 Dec;10(6):407-14. doi: 10.1006/scbi.2000.0337. Semin Cancer Biol. 2000. PMID: 11170863 Review.
Cited by
- Surface modification of implants in long bone.
Förster Y, Rentsch C, Schneiders W, Bernhardt R, Simon JC, Worch H, Rammelt S. Förster Y, et al. Biomatter. 2012 Jul-Sep;2(3):149-57. doi: 10.4161/biom.21563. Biomatter. 2012. PMID: 23507866 Free PMC article. Review. - Transcriptomic Analysis of Large Yellow Croaker (Larimichthys crocea) during Early Development under Hypoxia and Acidification Stress.
Wang Y, Chen R, Wang Q, Yue Y, Gao Q, Wang C, Zheng H, Peng S. Wang Y, et al. Vet Sci. 2022 Nov 12;9(11):632. doi: 10.3390/vetsci9110632. Vet Sci. 2022. PMID: 36423081 Free PMC article. - Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.
Mishra SK, Wheeler JJ, Pitake S, Ding H, Jiang C, Fukuyama T, Paps JS, Ralph P, Coyne J, Parkington M, DeBrecht J, Ehrhardt-Humbert LC, Cruse GP, Bäumer W, Ji RR, Ko MC, Olivry T. Mishra SK, et al. Cell Rep. 2020 Apr 7;31(1):107472. doi: 10.1016/j.celrep.2020.03.036. Cell Rep. 2020. PMID: 32268102 Free PMC article. - Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality.
Jones RG, Li X, Gray PD, Kuang J, Clayton F, Samowitz WS, Madison BB, Gumucio DL, Kuwada SK. Jones RG, et al. J Cell Biol. 2006 Nov 6;175(3):505-14. doi: 10.1083/jcb.200602160. J Cell Biol. 2006. PMID: 17088430 Free PMC article. - Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3.
Dang I, Brazzo JA, Bae Y, Assoian RK. Dang I, et al. J Cell Sci. 2023 Oct 1;136(19):jcs260636. doi: 10.1242/jcs.260636. Epub 2023 Oct 12. J Cell Sci. 2023. PMID: 37737020 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources