Therapeutic benefits from targeting of ADAM family members - PubMed (original) (raw)

Review

. 2004 Jun 15;43(23):7227-35.

doi: 10.1021/bi049677f.

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Review

Therapeutic benefits from targeting of ADAM family members

Marcia L Moss et al. Biochemistry. 2004.

Abstract

Members of the ADAM (a disintegrin and metalloproteinase) family of proteolytic enzymes are implicated in the processing of many single transmembrane-bound proteins ranging from cell surface receptors to growth factors and cytokines. Because of the biological significance of these processing events, a recurring theme in studying ADAM biology is that they are involved in physiological processes that can go awry and lead to disease states. This review provides a comprehensive look at ADAM family members and their role in pathology and provides a pathway for determining whether an enzyme is a physiological convertase for a given protein. In addition, ADAMs are discussed as potential therapeutic targets.

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