Extracorporeal shock waves promote healing of collagenase-induced Achilles tendinitis and increase TGF-beta1 and IGF-I expression - PubMed (original) (raw)

Extracorporeal shock waves promote healing of collagenase-induced Achilles tendinitis and increase TGF-beta1 and IGF-I expression

Yeung-Jen Chen et al. J Orthop Res. 2004 Jul.

Free article

Abstract

Extracorporeal shock waves (ESW) have recently been used in resolving tendinitis. However, mechanisms by which ESW promote tendon repair is not fully understood. In this study, we reported that an optimal ESW treatment promoted healing of Achilles tendintis by inducing TGF-beta1 and IGF-I. Rats with the collagenease-induced Achilles tendinitis were given a single ESW treatment (0.16 mJ/mm(2) energy flux density) with 0, 200, 500 and 1000 impulses. Achilles tendons were subjected to biomechanical (load to failure and stiffness), biochemical properties (DNA, glycosaminoglycan and hydroxyproline content) and histological assessment. ESW with 200 impulses restored biomechanical and biochemical characteristics of healing tendons 12 weeks after treatment. However, ESW treatments with 500 and 1000 impulses elicited inhibitory effects on tendinitis repair. Histological observation demonstrated that ESW treatment resolved edema, swelling, and inflammatory cell infiltration in injured tendons. Lesion site underwent intensive tenocyte proliferation, neovascularization and progressive tendon tissue regeneration. Tenocytes at the hypertrophied cellular tissue and newly developed tendon tissue expressed strong proliferating cell nuclear antigen (PCNA) after ESW treatment, suggesting that physical ESW could increase the mitogenic responses of tendons. Moreover, the proliferation of tenocytes adjunct to hypertrophied cell aggregate and newly formed tendon tissue coincided with intensive TGF-beta1 and IGF-I expression. Increasing TGF-beta1 expression was noted in the early stage of tendon repair, and elevated IGF-I expression was persisted throughout the healing period. Together, low-energy shock wave effectively promoted tendon healing. TGF-beta1 and IGF-I played important roles in mediating ESW-stimulated cell proliferation and tissue regeneration of tendon.

PubMed Disclaimer

Cited by

Case study: Treating infraspinatus and supraspinatus trigger points and supraspinatus tendinopathy utilizing piezoelectric shockwave.
Owen H. Owen H. Front Vet Sci. 2022 Oct 26;9:943276. doi: 10.3389/fvets.2022.943276. eCollection 2022. Front Vet Sci. 2022. PMID: 36387390 Free PMC article.
Percutaneous ultrasonic debridement of tendinopathy-a pilot Achilles rabbit model.
Kamineni S, Butterfield T, Sinai A. Kamineni S, et al. J Orthop Surg Res. 2015 May 20;10:70. doi: 10.1186/s13018-015-0207-7. J Orthop Surg Res. 2015. PMID: 25986341 Free PMC article.
Experimental studies on the biological effects of extracorporeal shock wave therapy on tendon models. A review of the literature.
Visco V, Vulpiani MC, Torrisi MR, Ferretti A, Pavan A, Vetrano M. Visco V, et al. Muscles Ligaments Tendons J. 2014 Nov 17;4(3):357-61. eCollection 2014 Jul. Muscles Ligaments Tendons J. 2014. PMID: 25489555 Free PMC article. Review.
Extracorporeal shock wave therapy is not useful after arthroscopic rotator cuff repair.
Kim JY, Lee JS, Park CW. Kim JY, et al. Knee Surg Sports Traumatol Arthrosc. 2012 Dec;20(12):2567-72. doi: 10.1007/s00167-012-1923-8. Epub 2012 Feb 21. Knee Surg Sports Traumatol Arthrosc. 2012. PMID: 22349603 Clinical Trial.

Extracorporeal shock waves promote healing of collagenase-induced Achilles tendinitis and increase TGF-beta1 and IGF-I expression - PubMed (original) (raw)