MAP1B is required for Netrin 1 signaling in neuronal migration and axonal guidance - PubMed (original) (raw)
Comparative Study
. 2004 May 25;14(10):840-50.
doi: 10.1016/j.cub.2004.04.046.
Christian González-Billault, Jesús M Ureña, Eva M Jiménez, María J Barallobre, Marta Pascual, Lluís Pujadas, Sergi Simó, Anna La Torre, Francisco Wandosell, Jesús Avila, Eduardo Soriano
Affiliations
- PMID: 15186740
- DOI: 10.1016/j.cub.2004.04.046
Free article
Comparative Study
MAP1B is required for Netrin 1 signaling in neuronal migration and axonal guidance
José A Del Río et al. Curr Biol. 2004.
Free article
Abstract
Background: The signaling cascades governing neuronal migration and axonal guidance link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the crosstalk between microtubules and actin filaments.
Results: Here we show that Netrin 1 regulates, both in vivo and in vitro, mode I MAP1B phosphorylation, which controls MAP1B activity, in a signaling pathway that depends essentially on the kinases GSK3 and CDK5. We also show that map1B-deficient neurons from the lower rhombic lip and other brain regions have reduced chemoattractive responses to Netrin 1 in vitro. Furthermore, map1B mutant mice have severe abnormalities, similar to those described in netrin 1-deficient mice, in axonal tracts and in the pontine nuclei.
Conclusions: These data indicate that MAP1B phosphorylation is controlled by Netrin 1 and that the lack of MAP1B impairs Netrin 1-mediated chemoattraction in vitro and in vivo. Thus, MAP1B may be a downstream effector in the Netrin 1-signaling pathway.
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