Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches - PubMed (original) (raw)
Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches
Marilyn Thien et al. Immunity. 2004 Jun.
Free article
Abstract
The role of BAFF in B cell self tolerance was examined by tracking the fate of anti-HEL self-reactive B cells in BAFF transgenic mice using four different models of self-reactive B cell deletion. BAFF overexpression did not affect the development of self-reactive B cells normally deleted in the bone marrow or during the early stages of peripheral development. By contrast, self-reactive B cells normally deleted around the late T2 stage of peripheral development were rescued from deletion, matured, and colonized the splenic follicle. Furthermore, self-reactive B cells normally selectively deleted from the marginal zone repopulated this compartment when excess BAFF was present. Self-reactive B cells rescued by excess BAFF were not anergic. BAFF overexpression therefore rescued only self-reactive B cells normally deleted with relatively low stringency and facilitated their migration into otherwise forbidden microenvironments. This partial subversion of B cell self tolerance is likely to underlie the autoimmunity associated with BAFF overexpression.
Comment in
- Tipping the scales of selection with BAFF.
Cancro MP. Cancro MP. Immunity. 2004 Jun;20(6):655-6. doi: 10.1016/j.immuni.2004.06.001. Immunity. 2004. PMID: 15189730
Similar articles
- Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells.
Fletcher CA, Sutherland AP, Groom JR, Batten ML, Ng LG, Gommerman J, Mackay F. Fletcher CA, et al. Eur J Immunol. 2006 Sep;36(9):2504-14. doi: 10.1002/eji.200636270. Eur J Immunol. 2006. PMID: 16906535 - The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF.
Tardivel A, Tinel A, Lens S, Steiner QG, Sauberli E, Wilson A, Mackay F, Rolink AG, Beermann F, Tschopp J, Schneider P. Tardivel A, et al. Eur J Immunol. 2004 Feb;34(2):509-18. doi: 10.1002/eji.200324692. Eur J Immunol. 2004. PMID: 14768056 - BAFF AND APRIL: a tutorial on B cell survival.
Mackay F, Schneider P, Rennert P, Browning J. Mackay F, et al. Annu Rev Immunol. 2003;21:231-64. doi: 10.1146/annurev.immunol.21.120601.141152. Epub 2001 Dec 19. Annu Rev Immunol. 2003. PMID: 12427767 Review. - Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells.
Gorelik L, Gilbride K, Dobles M, Kalled SL, Zandman D, Scott ML. Gorelik L, et al. J Exp Med. 2003 Sep 15;198(6):937-45. doi: 10.1084/jem.20030789. J Exp Med. 2003. PMID: 12975458 Free PMC article. - The life and death of a B cell.
Defrance T, Casamayor-Pallejà M, Krammer PH. Defrance T, et al. Adv Cancer Res. 2002;86:195-225. doi: 10.1016/s0065-230x(02)86006-7. Adv Cancer Res. 2002. PMID: 12374279 Review.
Cited by
- Therapeutic efficacy of rituximab combined with cyclosporin A on B-cell dysregulation in chronic graft-versus-host disease.
Fu XJ, Meng C, Guo L, Lin LE. Fu XJ, et al. Clin Transl Oncol. 2024 Sep 4. doi: 10.1007/s12094-024-03684-1. Online ahead of print. Clin Transl Oncol. 2024. PMID: 39231914 - BAFF neutralization impairs the autoantibody-mediated clearance of dead adipocytes and aggravates obesity-induced insulin resistance.
Lempicki MD, Gray JA, Abuna G, Murata RM, Divanovic S, McNamara CA, Meher AK. Lempicki MD, et al. Front Immunol. 2024 Aug 9;15:1436900. doi: 10.3389/fimmu.2024.1436900. eCollection 2024. Front Immunol. 2024. PMID: 39185417 Free PMC article. - Anti-B-Cell-Activating Factor (BAFF) Therapy: A Novel Addition to Autoimmune Disease Management and Potential for Immunomodulatory Therapy in Warm Autoimmune Hemolytic Anemia.
Cheekati M, Murakhovskaya I. Cheekati M, et al. Biomedicines. 2024 Jul 18;12(7):1597. doi: 10.3390/biomedicines12071597. Biomedicines. 2024. PMID: 39062171 Free PMC article. Review. - Autoimmune diseases and atherosclerotic cardiovascular disease.
Porsch F, Binder CJ. Porsch F, et al. Nat Rev Cardiol. 2024 Nov;21(11):780-807. doi: 10.1038/s41569-024-01045-7. Epub 2024 Jun 27. Nat Rev Cardiol. 2024. PMID: 38937626 Review. - The roles of adenosine signaling in systemic lupus erythematosus.
Dong K, Wu XN, Liu YQ, Yang L, Liu C, Wang HP, Gao ZW. Dong K, et al. Heliyon. 2024 Apr 17;10(9):e29848. doi: 10.1016/j.heliyon.2024.e29848. eCollection 2024 May 15. Heliyon. 2024. PMID: 38699049 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources