Epigenetic regulation of mammalian genomic imprinting - PubMed (original) (raw)

Review

Epigenetic regulation of mammalian genomic imprinting

Katia Delaval et al. Curr Opin Genet Dev. 2004 Apr.

Abstract

Imprinted genes play important roles in development, and most are clustered in large domains. Their allelic repression is regulated by 'imprinting control regions' (ICRs), which are methylated on one of the two parental alleles. Non-histone proteins and nearby sequence elements influence the establishment of this differential methylation during gametogenesis. DNA methylation, histone modifications, and also polycomb group proteins are important for the somatic maintenance of imprinting. The way ICRs regulate imprinting differs between domains. At some, the ICR constitutes an insulator that prevents promoter-enhancer interactions, when unmethylated. At other domains, non-coding RNAs could be involved, possibly by attracting chromatin-modifying complexes. The latter silencing mechanism has similarities with X-chromosome inactivation.

PubMed Disclaimer

Similar articles

• Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.
  Umlauf D, Goto Y, Cao R, Cerqueira F, Wagschal A, Zhang Y, Feil R. Umlauf D, et al. Nat Genet. 2004 Dec;36(12):1296-300. doi: 10.1038/ng1467. Epub 2004 Oct 31. Nat Genet. 2004. PMID: 15516932
• DNA methylation as a regulatory mechanism for gene expression in mammals.
  Serman A, Vlahović M, Serman L, Bulić-Jakus F. Serman A, et al. Coll Antropol. 2006 Sep;30(3):665-71. Coll Antropol. 2006. PMID: 17058541 Review.
• The imprinting box of the mouse Igf2r gene.
  Birger Y, Shemer R, Perk J, Razin A. Birger Y, et al. Nature. 1999 Jan 7;397(6714):84-8. doi: 10.1038/16291. Nature. 1999. PMID: 9892358
• Gamete-specific epigenetic mechanisms shape genomic imprinting.
  Jullien PE, Berger F. Jullien PE, et al. Curr Opin Plant Biol. 2009 Oct;12(5):637-42. doi: 10.1016/j.pbi.2009.07.004. Epub 2009 Aug 24. Curr Opin Plant Biol. 2009. PMID: 19709923 Review.

Cited by

• Genome-wide DNA methylation patterns in bumble bee (Bombus vosnesenskii) populations from spatial-environmental range extremes.
  Rahman SR, Lozier JD. Rahman SR, et al. Sci Rep. 2023 Sep 9;13(1):14901. doi: 10.1038/s41598-023-41896-7. Sci Rep. 2023. PMID: 37689750 Free PMC article.
• Defining Candidate Imprinted loci in Bos taurus.
  Bina M. Bina M. Genes (Basel). 2023 May 2;14(5):1036. doi: 10.3390/genes14051036. Genes (Basel). 2023. PMID: 37239396 Free PMC article.
• Mitochondrial DNA Deficiency and Supplementation in Sus scrofa Oocytes Influence Transcriptome Profiles in Oocytes and Blastocysts.
  Okada T, McIlfatrick S, St John JC. Okada T, et al. Int J Mol Sci. 2023 Feb 14;24(4):3783. doi: 10.3390/ijms24043783. Int J Mol Sci. 2023. PMID: 36835193 Free PMC article.
• Origin and Evolution of Marsupial-specific Imprinting Clusters Through Lineage-specific Gene Duplications and Acquisition of Promoter Differential Methylation.
  Cao W, Douglas KC, Samollow PB, VandeBerg JL, Wang X, Clark AG. Cao W, et al. Mol Biol Evol. 2023 Feb 3;40(2):msad022. doi: 10.1093/molbev/msad022. Mol Biol Evol. 2023. PMID: 36721950 Free PMC article.
• Does supplementation of oocytes with additional mtDNA influence developmental outcome?
  McIlfatrick S, O'Leary S, Okada T, Penn A, Nguyen VHT, McKenny L, Huang SY, Andreas E, Finnie J, Kirkwood R, St John JC. McIlfatrick S, et al. iScience. 2023 Jan 11;26(2):105956. doi: 10.1016/j.isci.2023.105956. eCollection 2023 Feb 17. iScience. 2023. PMID: 36711242 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database