Virulence factors for hemolytic uremic syndrome, Denmark - PubMed (original) (raw)

Virulence factors for hemolytic uremic syndrome, Denmark

Steen Ethelberg et al. Emerg Infect Dis. 2004 May.

Abstract

We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups O157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.

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Comment in

• Endogeneity in logistic regression models.
  Avery G. Avery G. Emerg Infect Dis. 2005 Mar;11(3):503-4; author reply 504-5. doi: 10.3201/eid1103.040462. Emerg Infect Dis. 2005. PMID: 15789492 Free PMC article. No abstract available.

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