The role of adaptor proteins in lymphocyte activation - PubMed (original) (raw)

Review

The role of adaptor proteins in lymphocyte activation

Mauro Togni et al. Mol Immunol. 2004 Jul.

Abstract

Research within the last 10 years has provided compelling evidence that adaptor proteins regulate the major pathways of lymphocyte activation. Based upon their differential subcellular localization, transmembrane adaptors and cytosolic adaptors can be distinguished. Here we review some of the most recent findings about both types of adaptor proteins which have facilitated our understanding how immunoreceptors control lymphocyte activation and differentiation.

PubMed Disclaimer

Similar articles

• Adaptors as central mediators of signal transduction in immune cells.
  Jordan MS, Singer AL, Koretzky GA. Jordan MS, et al. Nat Immunol. 2003 Feb;4(2):110-6. doi: 10.1038/ni0203-110. Nat Immunol. 2003. PMID: 12555096 Review.
• Adaptor proteins in lymphocyte activation.
  Janssen E, Zhang W. Janssen E, et al. Curr Opin Immunol. 2003 Jun;15(3):269-76. doi: 10.1016/s0952-7915(03)00044-x. Curr Opin Immunol. 2003. PMID: 12787751 Review.
• Transmembrane adaptor proteins: organizers of immunoreceptor signalling.
  Horejsí V, Zhang W, Schraven B. Horejsí V, et al. Nat Rev Immunol. 2004 Aug;4(8):603-16. doi: 10.1038/nri1414. Nat Rev Immunol. 2004. PMID: 15286727 Review. No abstract available.
• Transmembrane adaptor proteins in membrane microdomains: important regulators of immunoreceptor signaling.
  Horejsí V. Horejsí V. Immunol Lett. 2004 Mar 29;92(1-2):43-9. doi: 10.1016/j.imlet.2003.10.013. Immunol Lett. 2004. PMID: 15081526 Review.
• NTAL/LAB and LAT: a balancing act in mast-cell activation and function.
  Rivera J. Rivera J. Trends Immunol. 2005 Mar;26(3):119-22. doi: 10.1016/j.it.2005.01.001. Trends Immunol. 2005. PMID: 15745852 Review. No abstract available.

Cited by

• A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks.
  Conzelmann H, Saez-Rodriguez J, Sauter T, Kholodenko BN, Gilles ED. Conzelmann H, et al. BMC Bioinformatics. 2006 Jan 23;7:34. doi: 10.1186/1471-2105-7-34. BMC Bioinformatics. 2006. PMID: 16430778 Free PMC article.
• Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapter protein.
  Pan Z, Shen Y, Ge B, Du C, McKeithan T, Chan WC. Pan Z, et al. Br J Haematol. 2007 Jun;137(6):578-90. doi: 10.1111/j.1365-2141.2007.06597.x. Epub 2007 May 9. Br J Haematol. 2007. PMID: 17489982 Free PMC article.
• Syk and pTyr'd: Signaling through the B cell antigen receptor.
  Geahlen RL. Geahlen RL. Biochim Biophys Acta. 2009 Jul;1793(7):1115-27. doi: 10.1016/j.bbamcr.2009.03.004. Epub 2009 Mar 21. Biochim Biophys Acta. 2009. PMID: 19306898 Free PMC article. Review.
• RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.
  Ménasché G, Kliche S, Chen EJ, Stradal TE, Schraven B, Koretzky G. Ménasché G, et al. Mol Cell Biol. 2007 Jun;27(11):4070-81. doi: 10.1128/MCB.02011-06. Epub 2007 Apr 2. Mol Cell Biol. 2007. PMID: 17403904 Free PMC article.
• The adapter protein ADAP is required for selected dendritic cell functions.
  Togni M, Engelmann S, Reinhold D, Schraven B, Reinhold A. Togni M, et al. Cell Commun Signal. 2012 Jun 6;10(1):14. doi: 10.1186/1478-811X-10-14. Cell Commun Signal. 2012. PMID: 22672517 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Ovid Technologies, Inc.

• Miscellaneous

  • NCI CPTAC Assay Portal