A field guide to ubiquitylation - PubMed (original) (raw)

Review

A field guide to ubiquitylation

S Fang et al. Cell Mol Life Sci. 2004 Jul.

Abstract

The capacity for exquisite regulation of ubiquitylation provides eukaryotic cells with a means to fine-tune both protein function and levels. This complex set of processes affects myriad proteins and potentially impacts all cellular processes. Ubiquitylation is brought about through multienzyme processes, with specificity conferred primarily by interactions of substrates with specific ubiquitin protein ligases (E3s) in association with ubiquitin conjugating enzymes (E2s). Regulation of ubiquitylation occurs at multiple levels, including E2-E3 interactions, substrate recognition, chain elongation, binding of ubiquitin to conserved motifs and deubiquityation. This review presents the fundamentals of the ubiquitin conjugating system.

PubMed Disclaimer

References

1. 1. JAMA. 1983 Apr 8;249(14):1797-99, 1802-7 - PubMed
2. 1. N Engl J Med. 1983 Jun 9;308(23):1419 - PubMed
3. 1. Nature. 1987 Jan 15-21;325(6101):215-6 - PubMed
4. 1. J Am Soc Inf Sci. 1992 Aug;43(7):488-93 - PubMed
5. 1. Eur Heart J. 2009 Nov;30(22):2769-812 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Springer

• Other Literature Sources

  • The Lens - Patent Citations