Ubiquitin-free routes into the proteasome - PubMed (original) (raw)
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Ubiquitin-free routes into the proteasome
M A Hoyt et al. Cell Mol Life Sci. 2004 Jul.
Abstract
The majority of proteasome substrates identified to date are marked for degradation by polyubiquitinylation. Exceptions to this principle, however, are well documented and can help us understand the process proteasomes use to recognize their substrates. Examples include ornithine decarboxylase, p21/Cip1, TCRalpha, IkappaBalpha, c-Jun, calmodulin and thymidylate synthase. Degradation of these proteins can be completely ubiquitin-independent or coexist with ubiquitin-dependent pathways. Uncoupling degradation from ubiquitin modification may reflect the evolutionary conservation of mechanisms optimized for highly specialized regulatory functions.
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References
- JAMA. 2011 Apr 27;305(16):1677-84 - PubMed
- Stat Med. 2010 Mar 30;29(7-8):932-44 - PubMed
- Lancet. 2011 Apr 23;377(9775):1409-20 - PubMed
- J Am Coll Cardiol. 2008 Sep 30;52(14):1134-40 - PubMed
- EuroIntervention. 2009 May;5(1):115-20 - PubMed
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