Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS - PubMed (original) (raw)
. 2004 Jul 2;305(5680):93-6.
doi: 10.1126/science.1097775.
Affiliations
- PMID: 15232108
- DOI: 10.1126/science.1097775
Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS
Cristina Hidalgo Carcedo et al. Science. 2004.
Erratum in
- Science.2004 nOV 19;306(5700):1292
Abstract
Organelle inheritance is an essential feature of all eukaryotic cells. As with other organelles, the Golgi complex partitions between daughter cells through the fission of its membranes into numerous tubulovesicular fragments. We found that the protein CtBP3/BARS (BARS) was responsible for driving the fission of Golgi membranes during mitosis in vivo. Moreover, by in vitro analysis, we identified two stages of this Golgi fragmentation process: disassembly of the Golgi stacks into a tubular network, and BARS-dependent fission of these tubules. Finally, this BARS-induced fission of Golgi membranes controlled the G2-to-prophase transition of the cell cycle, and hence cell division.
Comment in
- Cell biology. The Golgi goes fission.
Diao A, Lowe M. Diao A, et al. Science. 2004 Jul 2;305(5680):48-9. doi: 10.1126/science.1100153. Science. 2004. PMID: 15232093 No abstract available.
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