Declining incidence of severe retinopathy and persisting decrease of nephropathy in an unselected population of Type 1 diabetes-the Linköping Diabetes Complications Study - PubMed (original) (raw)

. 2004 Jul;47(7):1266-1272.

doi: 10.1007/s00125-004-1431-6. Epub 2004 Jul 2.

Affiliations

• PMID: 15235773
• DOI: 10.1007/s00125-004-1431-6

Declining incidence of severe retinopathy and persisting decrease of nephropathy in an unselected population of Type 1 diabetes-the Linköping Diabetes Complications Study

M Nordwall et al. Diabetologia. 2004 Jul.

Abstract

Aims/hypothesis: In a previous study conducted over the last decades we found a decreased incidence of nephropathy but unchanged incidence of severe retinopathy among patients with Type 1 diabetes diagnosed in childhood and with 20 years duration of diabetes. The aim of our current study was to investigate the incidence 5 to 10 years later in the same population.

Methods: We studied all 269 patients in whom Type 1 diabetes was diagnosed in childhood between 1961 and 1985 in a district in southeastern Sweden. Ninety-one percent were monitored for retinopathy until at least 1997 and 95% were monitored for nephropathy. Severe retinopathy was defined as laser-treated retinopathy and nephropathy as persistent proteinuria. Survival analysis was used and the patients divided into five cohorts according to the time of onset of diabetes.

Results: The cumulative proportion of severe retinopathy had declined ( p=0.006). After 25 years it was 47% (95% CI 34-61), 28% (15-40) and 24% (12-36) in the cohorts 1961 to 1965, 1966 to 1970 and 1971 to 1975 respectively. After 30 years it was 53% (40-66) and 44% (28-59) in the oldest cohorts. The cumulative proportion of nephropathy after 25 years duration was 30% (18-42), 8% (1-16) and 13% (4-23) in the cohorts 1961 to 1965, 1966 to 1970 and 1971 to 1975 respectively. After 30 years, it was 32% (20-44) and 11% (2-20) for the oldest cohorts ( p<0.0001).

Conclusions/interpretation: In an unselected population with Type 1 diabetes diagnosed in childhood, modern diabetes care markedly reduced the incidence of severe retinopathy and nephropathy.

PubMed Disclaimer

Similar articles

• Unchanged incidence of severe retinopathy in a population of Type 1 diabetic patients with marked reduction of nephropathy.
  Bojestig M, Arnqvist HJ, Karlberg BE, Ludvigsson J. Bojestig M, et al. Diabet Med. 1998 Oct;15(10):863-9. doi: 10.1002/(SICI)1096-9136(199810)15:10<863::AID-DIA665>3.0.CO;2-O. Diabet Med. 1998. PMID: 9796888
• Good glycemic control remains crucial in prevention of late diabetic complications--the Linköping Diabetes Complications Study.
  Nordwall M, Arnqvist HJ, Bojestig M, Ludvigsson J. Nordwall M, et al. Pediatr Diabetes. 2009 May;10(3):168-76. doi: 10.1111/j.1399-5448.2008.00472.x. Epub 2008 Oct 22. Pediatr Diabetes. 2009. PMID: 19175900
• Incidence of retinopathy in type I (insulin-dependent) diabetes: association with clinical nephropathy.
  Kofoed-Enevoldsen A, Jensen T, Borch-Johnsen K, Deckert T. Kofoed-Enevoldsen A, et al. J Diabet Complications. 1987 Jul-Sep;1(3):96-9. doi: 10.1016/s0891-6632(87)80064-8. J Diabet Complications. 1987. PMID: 2969913
• Cardiovascular risk in the young type 1 diabetes population with a low 10-year, but high lifetime risk of cardiovascular disease.
  McVeigh GE, Gibson W, Hamilton PK. McVeigh GE, et al. Diabetes Obes Metab. 2013 Mar;15(3):198-203. doi: 10.1111/dom.12013. Epub 2012 Oct 24. Diabetes Obes Metab. 2013. PMID: 22998614 Review.
• Complications and prognosis of children with IDDM.
  Tajima N, Matsushima M. Tajima N, et al. Diabetes Res Clin Pract. 1994 Oct;24 Suppl:S165-70. doi: 10.1016/0168-8227(94)90245-3. Diabetes Res Clin Pract. 1994. PMID: 7859601 Review.

Cited by

• Progression and regression of kidney disease in type 1 diabetes.
  Jansson Sigfrids F, Groop PH. Jansson Sigfrids F, et al. Front Nephrol. 2023 Dec 14;3:1282818. doi: 10.3389/fneph.2023.1282818. eCollection 2023. Front Nephrol. 2023. PMID: 38192517 Free PMC article. Review.
• As Facts and Chats Go Online, What Is Important for Adolescents with Type 1 Diabetes?
  Nordfeldt S, Angarne-Lindberg T, Nordwall M, Ekberg J, Berterö C. Nordfeldt S, et al. PLoS One. 2013 Jun 21;8(6):e67659. doi: 10.1371/journal.pone.0067659. Print 2013. PLoS One. 2013. PMID: 23805322 Free PMC article.
• The incidences of and risk factors for severe retinopathy requiring photocoagulation and albuminuria in Japanese patients with childhood-onset type 1 diabetes.
  Takaike H, Uchigata Y, Matsuura N, Sasaki N, Amemiya S, Urakami T, Kawamura T, Kikuchi N, Sugihara S; Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT). Takaike H, et al. Diabetol Int. 2017 Sep 22;9(2):121-128. doi: 10.1007/s13340-017-0336-9. eCollection 2018 May. Diabetol Int. 2017. PMID: 30603359 Free PMC article.
• Current concepts in diabetic retinopathy.
  Song SJ, Wong TY. Song SJ, et al. Diabetes Metab J. 2014 Dec;38(6):416-25. doi: 10.4093/dmj.2014.38.6.416. Diabetes Metab J. 2014. PMID: 25541604 Free PMC article. Review.
• Tolerance of Vascularized Islet-Kidney Transplants in Rhesus Monkeys.
  Pathiraja V, Villani V, Tasaki M, Matar AJ, Duran-Struuck R, Yamada R, Moran SG, Clayman ES, Hanekamp J, Shimizu A, Sachs DH, Huang CA, Yamada K. Pathiraja V, et al. Am J Transplant. 2017 Jan;17(1):91-102. doi: 10.1111/ajt.13952. Epub 2016 Aug 9. Am J Transplant. 2017. PMID: 27376692 Free PMC article.

References

1. 1. Br J Ophthalmol. 1996 Feb;80(2):135-9 - PubMed
2. 1. N Engl J Med. 1984 Jul 12;311(2):89-93 - PubMed
3. 1. Diabet Med. 1998;15 Suppl 4:S51-6 - PubMed
4. 1. Diabetologia. 1985 Aug;28(8):590-6 - PubMed
5. 1. Diabetes Care. 2001 May;24(5):823-7 - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Springer

• Medical

  • MedlinePlus Health Information