Linking tumor suppression, DNA damage and the anaphase-promoting complex - PubMed (original) (raw)

Review

Linking tumor suppression, DNA damage and the anaphase-promoting complex

Peter K Jackson. Trends Cell Biol. 2004 Jul.

Abstract

A recent study shows that the RASSF1A tumor suppressor functions as a regulator of the ordered proteolytic steps that organize mitosis. By controlling the stability of microtubules and the activity of the anaphase-promoting complex (APC), RASSF1A might provide a crucial link between mechanisms of tumor suppression and mitotic cell division. Furthermore, another recent study shows that protein kinase A, which is a key growth regulator, inhibits the APC during mitosis in yeast.

PubMed Disclaimer

Similar articles

• Control of APC-Cdc20 by the tumor suppressor RASSF1A.
  Song MS, Lim DS. Song MS, et al. Cell Cycle. 2004 May;3(5):574-6. Epub 2004 May 25. Cell Cycle. 2004. PMID: 15107619
• The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex.
  Song MS, Song SJ, Ayad NG, Chang JS, Lee JH, Hong HK, Lee H, Choi N, Kim J, Kim H, Kim JW, Choi EJ, Kirschner MW, Lim DS. Song MS, et al. Nat Cell Biol. 2004 Feb;6(2):129-37. doi: 10.1038/ncb1091. Epub 2004 Jan 25. Nat Cell Biol. 2004. PMID: 14743218
• The tumor suppressor RASSF1A does not interact with Cdc20, an activator of the anaphase-promoting complex.
  Liu L, Baier K, Dammann R, Pfeifer GP. Liu L, et al. Cell Cycle. 2007 Jul 1;6(13):1663-5. doi: 10.4161/cc.6.13.4435. Epub 2007 May 11. Cell Cycle. 2007. PMID: 17598981
• Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis.
  Eckerdt F, Strebhardt K. Eckerdt F, et al. Cancer Res. 2006 Jul 15;66(14):6895-8. doi: 10.1158/0008-5472.CAN-06-0358. Cancer Res. 2006. PMID: 16849530 Review.
• Proteolytic ratchets that control progression through mitosis.
  Townsley FM, Ruderman JV. Townsley FM, et al. Trends Cell Biol. 1998 Jun;8(6):238-44. doi: 10.1016/s0962-8924(98)01268-9. Trends Cell Biol. 1998. PMID: 9695848 Review.

Cited by

• The Ras-association domain family (RASSF) members and their role in human tumourigenesis.
  van der Weyden L, Adams DJ. van der Weyden L, et al. Biochim Biophys Acta. 2007 Sep;1776(1):58-85. doi: 10.1016/j.bbcan.2007.06.003. Epub 2007 Jul 4. Biochim Biophys Acta. 2007. PMID: 17692468 Free PMC article. Review.
• Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis.
  Fujita T, Liu W, Doihara H, Wan Y. Fujita T, et al. Am J Pathol. 2008 Jul;173(1):217-28. doi: 10.2353/ajpath.2008.070957. Epub 2008 Jun 5. Am J Pathol. 2008. PMID: 18535175 Free PMC article.
• Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor.
  Liu W, Xin H, Eckert DT, Brown JA, Gnarra JR. Liu W, et al. Oncogene. 2011 Jan 6;30(1):21-31. doi: 10.1038/onc.2010.395. Epub 2010 Aug 30. Oncogene. 2011. PMID: 20802534 Free PMC article.
• The RASSF1A Tumor Suppressor Binds the RasGAP DAB2IP and Modulates RAS Activation in Lung Cancer.
  Harrell Stewart DR, Schmidt ML, Donninger H, Clark GJ. Harrell Stewart DR, et al. Cancers (Basel). 2020 Dec 17;12(12):3807. doi: 10.3390/cancers12123807. Cancers (Basel). 2020. PMID: 33348649 Free PMC article.
• An in vivo study of Cdh1/APC in breast cancer formation.
  Fujita T, Liu W, Doihara H, Wan Y. Fujita T, et al. Int J Cancer. 2009 Aug 15;125(4):826-36. doi: 10.1002/ijc.24399. Int J Cancer. 2009. PMID: 19350629 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database