Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1 - PubMed (original) (raw)

Comparative Study

doi: 10.1038/nm1079. Epub 2004 Jul 11.

Affiliations

• PMID: 15247912
• DOI: 10.1038/nm1079

Comparative Study

Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1

Marisa I Gómez et al. Nat Med. 2004 Aug.

Abstract

Staphylococcus aureus is a major human pathogen that is associated with diverse types of local and systemic infection characterized by inflammation dominated by polymorphonuclear leukocytes. Staphylococci frequently cause pneumonia, and these clinical isolates often have increased expression of protein A, suggesting that this protein may have a role in virulence. Here we show that TNFR1, a receptor for tumor-necrosis factor-alpha (TNF-alpha) that is widely distributed on the airway epithelium, is a receptor for protein A. We also show that the protein A-TNFR1 signaling pathway has a central role in the pathogenesis of staphylococcal pneumonia.

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Comment in

• Staphylococcal protein A inflames the lungs.
  Normark BH, Normark S, Norrby-Teglund A. Normark BH, et al. Nat Med. 2004 Aug;10(8):780-1. doi: 10.1038/nm0804-780. Nat Med. 2004. PMID: 15286774 No abstract available.

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